Issue 8/2021
Content (28 Articles)
Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment
Varun Sasidharan Nair, Reem Saleh, Salman M. Toor, Farhan S. Cyprian, Eyad Elkord
Correction to: Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment
Varun Sasidharan Nair, Reem Saleh, Salman M. Toor, Farhan S. Cyprian, Eyad Elkord
Loss of type I IFN responsiveness impairs natural killer cell antitumor activity in breast cancer
Damien J. Zanker, Katie L. Owen, Nikola Baschuk, Alex J. Spurling, Belinda S. Parker
Therapeutic vaccination targeting CD40 and TLR3 controls melanoma growth through existing intratumoral CD8 T cells without new T cell infiltration
Aaron D. Stevens, Timothy N. J. Bullock
Characterization and comparison of innate and adaptive immune responses at vaccine sites in melanoma vaccine clinical trials
Marit M. Melssen, Karlyn E. Pollack, Max O. Meneveau, Mark E. Smolkin, Joel Pinczewski, Alexander F. Koeppel, Stephen D. Turner, Katia Sol-Church, Alexandra Hickman, Donna H. Deacon, Gina R. Petroni, Craig L. Slingluff Jr
Dopamine improves chemotherapeutic efficacy for pancreatic cancer by regulating macrophage-derived inflammations
Qiaofei Liu, Ronghua Zhang, Xiang Zhang, Jingkai Liu, Huanwen Wu, Yuan Li, Ming Cui, Tong Li, Huixin Song, Junyi Gao, Yalu Zhang, Sen Yang, Quan Liao
Tumor-draining lymph nodes are survival niches that support T cell priming against lymphatic transported tumor antigen and effects of immune checkpoint blockade in TNBC
Meghan J. O’Melia, Margaret P. Manspeaker, Susan N. Thomas
Preexisting autoimmune disease and immune-related adverse events associated with anti-PD-1 cancer immunotherapy: a national case series from the Canadian Research Group of Rheumatology in Immuno-Oncology
Sabrina Hoa, Linda Laaouad, Janet Roberts, Daniel Ennis, Carrie Ye, Karam Al Jumaily, Janet Pope, Tatiana Nevskaya, Alexandra Saltman, Megan Himmel, Robert Rottapel, Christina Ly, Ines Colmegna, Aurore Fifi-Mah, Nancy Maltez, Annaliese Tisseverasinghe, Marie Hudson, Shahin Jamal
Cytokine changes during immune-related adverse events and corticosteroid treatment in melanoma patients receiving immune checkpoint inhibitors
Kevin Tyan, Joanna Baginska, Martha Brainard, Anita Giobbie-Hurder, Mariano Severgnini, Michael Manos, Rizwan Haq, Elizabeth I. Buchbinder, Patrick A. Ott, F. Stephen Hodi, Osama E. Rahma
Immunotherapy response modeling by ex-vivo organ culture for lung cancer
Iris Kamer, Elizabeta Bab-Dinitz, Oranit Zadok, Efrat Ofek, Teodor Gottfried, Inbal Daniel-Meshulam, Goni Hout-Siloni, Alon Ben Nun, Iris Barshack, Amir Onn, Jair Bar
LncRNA UCA1 attenuated the killing effect of cytotoxic CD8 + T cells on anaplastic thyroid carcinoma via miR-148a/PD-L1 pathway
Xiaoming Wang, Yan Zhang, Jian Zheng, Cuixian Yao, Xiubo Lu
miR-34a induces immunosuppression in colorectal carcinoma through modulating a SIRT1/NF-κB/B7-H3/TNF-α axis
Fanyi Meng, Man Yang, Yinshuang Chen, Weichang Chen, Weipeng Wang
Single-cell RNA sequencing reveals cellular and molecular immune profile in a Pembrolizumab-responsive PD-L1-negative lung cancer patient
Runbo Zhong, Yunbin Zhang, Dongfang Chen, Shuhui Cao, Baohui Han, Hua Zhong
Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis
Sabrina Traxel, Julia Lehmann, Stefanie Richard, Semjon Sidorov, Felix Niggli, Christoph Berger, David Nadal, Simone Bürgler
T-VEC for stage IIIB-IVM1a melanoma achieves high rates of complete and durable responses and is associated with tumor load: a clinical prediction model
Emma H. A. Stahlie, Viola Franke, Charlotte L. Zuur, Willem M. C. Klop, Bernies van der Hiel, Bart A. Van de Wiel, Michel W. J. M. Wouters, Yvonne M. Schrage, Winan J. van Houdt, Alexander C. J. van Akkooi
A critical role of STING-triggered tumor-migrating neutrophils for anti-tumor effect of intratumoral cGAMP treatment
Marino Nagata, Akemi Kosaka, Yuki Yajima, Syunsuke Yasuda, Mizuho Ohara, Kenzo Ohara, Shohei Harabuchi, Ryusuke Hayashi, Hiroshi Funakoshi, Jun Ueda, Takumi Kumai, Toshihiro Nagato, Kensuke Oikawa, Yasuaki Harabuchi, Celis Esteban, Takayuki Ohkuri, Hiroya Kobayashi
The surgical perspective in neoadjuvant immunotherapy for resectable non-small cell lung cancer
Long Jiang, Jia Huang, Shanshan Jiang, Wenwen Rong, Yaofeng Shen, Chongwu Li, Yu Tian, Junwei Ning, Xiaoke Chen, Yunhai Yang, Zhengping Ding, Ziming Li, Qingquan Luo
The predictive value of body mass index on prognosis and adverse events of cancers treated with immunotherapy: a systematic review and meta-analysis
Yafei You, Chang Jiang, Kunwei Peng, Wenzhuo He, Lei Wang, Yanan Jin, Liangping Xia
Correction to: The predictive value of body mass index on prognosis and adverse events of cancers treated with immunotherapy: a systematic review and meta‑analysis
Yafei You, Chang Jiang, Kunwei Peng, Wenzhuo He, Lei Wang, Yanan Jin, Liangping Xia
Interleukin 17A promotes cell migration, enhances anoikis resistance, and creates a microenvironment suitable for triple negative breast cancer tumor metastasis
Yi-Fang Tsai, Chi-Cheng Huang, Yen-Shu Lin, Chih-Yi Hsu, Ching-Po Huang, Chun-Yu Liu, Jen-Hwey Chiu, Ling-Ming Tseng
CD30+OX40+ Treg is associated with improved overall survival in colorectal cancer
Jian Hang Lam, Michelle Hong, Si-Lin Koo, Clarinda Wei Ling Chua, Kah Ling Lim, Felicia Wee, Wei Keat Wan, Wei Qiang Leow, Joo Guan Yeo, Iain Bee Huat Tan, Joe Yeong, Tony Kiat Hon Lim, Tong Seng Lim
Tumor mutation score is more powerful than tumor mutation burden in predicting response to immunotherapy in non-small cell lung cancer
Yuan Li, Zuhua Chen, Weiping Tao, Nan Sun, Jie He
CAR19/22 T cell therapy in adult refractory Burkitt’s lymphoma
Xiaoxi Zhou, Tong Ge, Tongjuan Li, Liang Huang, Yang Cao, Yi Xiao, Miao Zhen, Liting Chen, Jianfeng Zhou
Pembrolizumab-induced immune-mediated fatal colitis with concurrent giardia infection
Gurhan Sisman, Erol Barbur, Didem Saka, Sibel Erdamar Cetin
Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden
Ramin Salehi-Rad, Rui Li, Linh M. Tran, Raymond J. Lim, Jensen Abascal, Milica Momcilovic, Stacy J. Park, Stephanie L. Ong, Maryam Shabihkhani, Zi Ling Huang, Manash Paul, David B. Shackelford, Kostyantyn Krysan, Bin Liu, Steven M. Dubinett
Activity of tumor-associated macrophage depletion by CSF1R blockade is highly dependent on the tumor model and timing of treatment
Sarah A. O’Brien, Jessica Orf, Katarzyna M. Skrzypczynska, Hong Tan, Jennie Kim, Jason DeVoss, Brian Belmontes, Jackson G. Egen
Mast cell proliferation in the cerebrospinal fluid after intraventricular administration of anti-B7H3 immunotherapy
Kim Kramer, Maria A. Donzelli, Melissa S. Pessin
Correction to: Mast cell proliferation in the cerebrospinal fluid after intraventricular administration of anti‑B7H3 immunotherapy
Kim Kramer, Maria A. Donzelli, Melissa S. Pessin