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Cancer Chemotherapy and Pharmacology

Issue 4/2023

Content (8 Articles)

Pharmacokinetics Review Article

Application of physiologically based pharmacokinetics modeling in the research of small-molecule targeted anti-cancer drugs

Xiaowen Wang, Fang Chen, Nan Guo, Zhichun Gu, Houwen Lin, Xiaoqiang Xiang, Yufei Shi, Bing Han

Ramucirumab Original Article

Effect of massive ascites on ramucirumab pharmacokinetics in patients with gastrointestinal cancers: a population pharmacokinetic analysis

Takuya Kaneko, Kosuke Doki, Takeshi Yamada, Yoshiyuki Yamamoto, Toshikazu Moriwaki, Yoshiharu Suzuki, Masato Homma

Gastric Cancer Original Article

Clinical implications and chemo-sensitivity of adjuvant chemotherapy in patients with poorly cohesive cells-gastric cancer

Jin Ho Baek, Byung Woog Kang, Hyojeung Kang, Miyeon Cho, Oh Kyoung Kwon, Ji Yeon Park, Ki Bum Park, An Na Seo, Jong Gwang Kim

Open Access Pancreatic Cancer Original Article

Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma

Hidemi Nishi, Kunihito Gotoh, Yoshito Tomimaru, Shogo Kobayashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi

Afatinib Original Article

Effects of polymorphisms in pregnane X receptor and ABC transporters on afatinib in Japanese patients with non-small cell lung cancer: pharmacogenomic–pharmacokinetic and exposure–response analysis

Hayato Yokota, Kazuhiro Sato, Sho Sakamoto, Yuji Okuda, Mariko Asano, Masahide Takeda, Katsutoshi Nakayama, Masatomo Miura

Open Access Acute Lymphoblastic Leukemia Short Communication

Excessive vincristine exposure in a child being treated for acute lymphoblastic leukaemia with underlying Dubin–Johnson syndrome: a case report

Shelby Barnett, Aye Chan Nyein, Martin Galler, David Jamieson, Michelle Davies, Philip Connor, Gareth J. Veal

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine