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Abdominal Radiology
Published in: Abdominal Radiology 10/2023

06-07-2023 | Autoimmune Pancreatitis | Review

Multimodality pictorial review of IgG4-related disease in the abdomen and pelvis

Authors: Suzanne Czerniak, Aditya Rao, Mahan Mathur

Published in: Abdominal Radiology | Issue 10/2023

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Abstract

Background

Immunoglobulin G4-related disease (IgG4-RD) is a systemic, immune-mediated disease that can affect multiple organs, including the orbits, salivary glands, thyroid gland, lungs, aorta, pancreas, bile ducts, lymph nodes, and retroperitoneum. While timely diagnosis is particularly important given the efficacy of glucocorticoid treatment for IgG4-RD, accurate recognition can prove a challenge given the overlap between the imaging features of this disease and other entities.

Purpose

After a review of the epidemiology, pathophysiology, and clinical considerations (including treatment) associated with IgG4-RD, this pictorial review will showcase the variable imaging manifestations of this disease in the abdomen and pelvis. Post-treatment imaging appearance of these entities will be reviewed and mimickers of this disease in the abdomen and pelvis will be presented.

Conclusion

The presence of mass-like soft tissue with radiographic characteristics of fibrosis affecting multiple organs should raise suspicion for IgG4-RD, although definite diagnosis can only be made with appropriate clinical, serological, and pathologic data.

Graphical abstract

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Metadata
Title
Multimodality pictorial review of IgG4-related disease in the abdomen and pelvis
Authors
Suzanne Czerniak
Aditya Rao
Mahan Mathur
Publication date
06-07-2023
Publisher
Springer US
Published in
Abdominal Radiology / Issue 10/2023
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-023-03996-w

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