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At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
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Journal of Clinical Immunology
Literature
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Mazereeuw-Hautier J, Leclerc EA, Simon M, Serre G, Jonca N. A novel mutation in CDSN causes peeling skin disease in a patient from Morocco. Br J Dermatol. 2011;165:1152–5.CrossRef
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Igawa S, Kishibe M, Honma M, Murakami M, Mizuno Y, Suga Y, et al. Aberrant distribution patterns of corneodesmosomal components of tape-stripped corneocytes in atopic dermatitis and related skin conditions (ichthyosis vulgaris, Netherton syndrome and peeling skin syndrome type B). J Dermatol Sci. 2013;72:54–60.CrossRef
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Mallet A, Kypriotou M, George K, Leclerc E, Rivero D, Mazereeuw-Hautier J, et al. Identification of the first nonsense CDSN mutation with expression of a truncated protein causing peeling skin syndrome type B. Br J Dermatol. 2013;169:1322–5.CrossRef
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Li J, Leyva-Castillo JM, Hener P, Eisenmann A, Zaafouri S, Jonca N, et al. Counterregulation between thymic stromal lymphopoietin– and IL-23–driven immune axes shapes skin inflammation in mice with epidermal barrier defects. J Allergy Clin Immunol. 2016;138:150-161.e13.CrossRef
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Sogkas G, Hirsch S, Jablonka A, Witte T, Schmidt RE, Atschekzei F. Dupilumab to treat severe atopic dermatitis in autosomal dominant hyper-IgE syndrome. Clinical Immunology. 2020;215:108452.CrossRef
Metadata
Title
Peeling Skin Syndrome Type 1: Dupilumab Reduces IgE, But Not Skin Anomalies
Authors
Barranca Alexis
Jonca Nathalie
Martin-Blondel Audrey
Apoil Pol-André
Mazereeuw-Hautier Juliette
Publication date
23-02-2022
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 4/2022
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-021-01194-1

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Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

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