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Published in: Virology Journal 1/2021

Open Access 01-12-2021 | Hepatitis B | Review

Functional cure for chronic hepatitis B: accessibility, durability, and prognosis

Authors: Aixin Song, Xiao Lin, Xinyue Chen

Published in: Virology Journal | Issue 1/2021

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Abstract

Hepatitis B surface antigen (HBsAg) clearance is regarded as the ideal endpoint for antiviral treatment in terms of drug withdrawal safety and improvements in prognosis. However, the overall rate of HBsAg clearance is low and differs based on treatment method and course. The recent application of combined and extended treatment strategies have improved the HBsAg clearance rate, and several patients achieved HBsAg clearance in clinical treatment. In addition, the durability of and clinical outcomes after HBsAg clearance have become the focus of both researchers and clinicians. This article reviews HBsAg clearance in terms of accessibility, durability, improvements in prognosis and relevant advances.
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Metadata
Title
Functional cure for chronic hepatitis B: accessibility, durability, and prognosis
Authors
Aixin Song
Xiao Lin
Xinyue Chen
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2021
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-021-01589-x

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