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BMC Neurology

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01-12-2020 | Amphotericin B | Case report

Disseminated Cryptococcosis revealed by transverse myelitis in Immunocompetent patient: a case report and review of the literature

Authors: Fangfang Qu, Zhenzhen Qu, Yingqian Lv, Bo Song, Bailin Wu

Published in: BMC Neurology | Issue 1/2020

Abstract

Background

Transverse myelitis (TM) is due to inflammatory spinal cord injury with bilateral neurologic involvement, which is sensory, motor, or autonomic in nature. It may be associated with autoimmune disease, vaccination, intoxication and infections. The most common infection cause of TM is Coxsackie virus and Mycoplasma pneumoniae. The cryptococcosis is rare. We present the case of disseminated cryptococcosis revealed by transverse myelitis in an immunocompetent 55-year-old male patient. The literature review is also stated.

Case presentation

The 55-year-old man suffered from gradual numbness, weakness in both lower limbs and finally paralyzed in the bed. The thoracic spine Computed tomography (CT) was normal, but multiple nodules in the lung were accidentally discovered. Thoracic Magnetic Resonance Imaging (MRI) showed diffused thoracic spinal cord thickening and extensively intramedullary T2 hyper intensity areas. Gadolinium contrast enhanced T1WI showed an intramedullary circle-enhanced nodule at 9th thoracic level. Diagnosis was made by histological examination of the bilateral lung biopsy. The patient was treated successfully with systemic amphotericin B liposome and fluconazole and intrathecal dexamethasone and amphotericin B liposome.

Conclusions

This is a patient with disseminated cryptococcosis involving the lung, spinal cord and adrenal glands, which is rare in the absence of immunodeficiency.

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Title: Disseminated Cryptococcosis revealed by transverse myelitis in Immunocompetent patient: a case report and review of the literature
Authors: Fangfang Qu
Zhenzhen Qu
Yingqian Lv
Bo Song
Bailin Wu
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Amphotericin B
Tuberculosis
Magnetic Resonance Imaging
Magnetic Resonance Imaging
Computed Tomography
Fluconazole
Computed Tomography
Tuberculosis
Cryptococcosis
Pneumonia
Published in: BMC Neurology / Issue 1/2020
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-020-1598-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Disseminated Cryptococcosis revealed by transverse myelitis in Immunocompetent patient: a case report and review of the literature

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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