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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 4/2021

01-08-2021 | Alzheimer's Disease | Original Article

Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age

Authors: G. Roberts, MPhys, MSc, J. J. Lloyd, BSc, MSc, PhD, J. P. M. Kane, PhD, R. Durcan, MBBS, S. Lawley, MBBS, K. Howe, BSc, G. S. Petrides, MBBS, J. T. O’Brien, DM, A. J. Thomas, PhD

Published in: Journal of Nuclear Cardiology | Issue 4/2021

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Abstract

Purpose

Cardiac 123I-MIBG image interpretation is affected by population differences and technical factors. We recruited older adults without cognitive decline and compared their cardiac MIBG uptake with results from the literature.

Methods

Phantom calibration confirmed that cardiac uptake results from Japan could be applied to our center. We recruited 31 controls, 17 individuals with dementia with Lewy bodies (DLB) and 15 with Alzheimer’s disease (AD). Images were acquired 20 minutes and four hours after injection using Siemens cameras with medium-energy low-penetration (MELP) collimators. Local normal heart-to-mediastinum (HMR) ratios were compared to Japanese results.

Results

Siemens gamma cameras with MELP collimators should give HMRs very close to the calibrated values used in Japan. However, our cut-offs with controls were lower at 2.07 for early and 1.86 for delayed images. Applying our lower cut-off to the dementia patients may increase the specificity of cardiac MIBG imaging for DLB diagnosis in a UK population without reducing sensitivity.

Conclusions

Our local HMR cut-off values are lower than in Japan, higher than in a large US study but similar to those found in another UK center. UK centers using other cameras and collimators may need to use different cut-offs to apply our results.
Appendix
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Metadata
Title
Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age
Authors
G. Roberts, MPhys, MSc
J. J. Lloyd, BSc, MSc, PhD
J. P. M. Kane, PhD
R. Durcan, MBBS
S. Lawley, MBBS
K. Howe, BSc
G. S. Petrides, MBBS
J. T. O’Brien, DM
A. J. Thomas, PhD
Publication date
01-08-2021
Publisher
Springer International Publishing
Published in
Journal of Nuclear Cardiology / Issue 4/2021
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-019-01887-6

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