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21-10-2023 | Alzheimer's Disease | Original Article

Age-related hearing loss is not linked to cerebrospinal fluid levels of β-amyloid or p-tau181

Authors: Francisco Martínez-Dubarbie, David Lobo, María Rollán-Martínez-Herrera, Sara López-García, Carmen Lage, Marta Fernández-Matarrubia, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Bravo, Ramón Cobo, Daniel Cabieces-Juncal, Marcos López-Hoyos, Juan Irure-Ventura, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez

Published in: Neurological Sciences | Issue 4/2024

Abstract

Introduction

As Hearing loss and dementia affect people with the same profile, several epidemiological studies have evaluated their relationship. However, the link between age-related hearing loss and Alzheimer’s disease is still unclear.

Methods

We selected subjects with no history of exposure to loud noises, blasts, head trauma with hearing loss, or sudden sensorineural hearing loss from a cohort intended to study preclinical phases of Alzheimer’s disease. Participants are volunteers over 55 years without cognitive impairment. We correlated the results of an objective auditory evaluation with brain amyloid and p-tau181 levels and with the outcomes of a comprehensive neuropsychological assessment.

Results

Fifty-five subjects at different stages of the Alzheimer's disease continuum were evaluated. There were no statistically significant correlations between amyloid-β and p-tau levels and any of the objective auditory measures. A weak but significant correlation was found between amyloid-β values and the Hearing Handicap Inventory for the Elderly. The neuropsychological domains more correlated to hearing loss were executive function and processing speed.

Discussion

Age-related hearing loss is not linked to any pathological markers of Alzheimer's disease nor to neuropsychological domains typically affected in this disease. The Hearing Handicap Inventory for the Elderly has an important component of subjectivity and further studies are needed to explore its relationship with amyloid-β levels.

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Title: Age-related hearing loss is not linked to cerebrospinal fluid levels of β-amyloid or p-tau181
Authors: Francisco Martínez-Dubarbie
David Lobo
María Rollán-Martínez-Herrera
Sara López-García
Carmen Lage
Marta Fernández-Matarrubia
Ana Pozueta-Cantudo
María García-Martínez
Andrea Corrales-Pardo
María Bravo
Ramón Cobo
Daniel Cabieces-Juncal
Marcos López-Hoyos
Juan Irure-Ventura
Pascual Sánchez-Juan
Eloy Rodríguez-Rodríguez
Publication date: 21-10-2023
Publisher: Springer International Publishing
Keywords: Alzheimer's Disease
Alzheimer's Disease
Biomarkers
Published in: Neurological Sciences / Issue 4/2024
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-023-07143-7

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Springer Medicine

Age-related hearing loss is not linked to cerebrospinal fluid levels of β-amyloid or p-tau181

Abstract

Introduction

Methods

Results

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Discussion

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