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11-11-2023 | Chronic Kidney Disease | Original Article

Progressive multifocal leukoencephalopathy in patients with chronic kidney disease

Authors: Jennifer Meylor, Daniel Crespo Artunduaga, Michael Mendoza, Sam I. Hooshmand, Ahmed Z. Obeidat

Published in: Neurological Sciences | Issue 4/2024

Abstract

Progressive multifocal leukoencephalopathy (PML) is an opportunistic central nervous system infection caused by the human polyomavirus 2, leading to demyelination from oligodendrocyte death and rapid neurologic decline. Most commonly, PML affects patients in immunocompromised states. However, rare reports of PML in an immunocompetent host exist. Here, we report two cases of PML in older individuals with chronic kidney disease (CKD). CKD can ultimately lead to immune system dysfunction and place patients in a relatively immunosuppressed state. Testing for JC virus should remain a consideration for rapid, unexplained neurologic decline even without known immunocompromised status in the appropriate clinical setting.

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Title: Progressive multifocal leukoencephalopathy in patients with chronic kidney disease
Authors: Jennifer Meylor
Daniel Crespo Artunduaga
Michael Mendoza
Sam I. Hooshmand
Ahmed Z. Obeidat
Publication date: 11-11-2023
Publisher: Springer International Publishing
Keyword: Chronic Kidney Disease
Published in: Neurological Sciences / Issue 4/2024
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-023-07182-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Progressive multifocal leukoencephalopathy in patients with chronic kidney disease

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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