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Neurological Sciences

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13-11-2023 | Stroke | Original Article

Clinical analysis of twenty-one cases of acute ischemic stroke related to Trousseau syndrome

Authors: Bingqing Zhao, Weihua Jia, Ye Yuan, Zheng Li

Published in: Neurological Sciences | Issue 4/2024

Abstract

Background

Trousseau syndrome (TS) is relatively rare and easily overlooked by clinicians, causing misdiagnosis and affecting subsequent treatment.

Objective

In this study, clinical features, laboratory examination, imaging features, treatment, and prognosis of patients with TS were discussed.

Methods and material

From February 2018 to April 2022, cases of 21 patients with malignant tumors complicated by acute ischemic stroke (AIS) were admitted to the Neurology Department of the hospital, and were retrospectively analyzed and discussed based on the literature.

Results

Twenty-one cases were included in the study. Of these, 95.23% (20/21) developed AIS 6–21 months after the onset of malignant tumors, 9.52% (2/21) had ischemic stroke as the first symptom, 4.76% (1/21) had recurrent ischemic stroke, and 14.29% (3/21) subsequently experienced venous and arterial thrombosis events; 80.95% (17/21) were pathologically confirmed to have adenocarcinoma; and 90.47% (19/21) of infarction cases involved multiple blood vessel feeding sites. MRI showed multiregional, multifocal patchy infarcts. d-dimer concentration was higher than normal in all patients. In addition, 61.90% (13/21) of the patients had poor outcomes according to mRS.

Conclusion

TS is a rare clinical type. It is often associated with adenocarcinoma, and the treatment is different from that of conventional cerebral infarction and the prognosis is very poor. In clinical practice, for AIS of unknown cause, if MRI shows multiple small lesions accompanied by a significant increase in d-dimer, routine screening for latent malignant tumors is recommended.

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Title: Clinical analysis of twenty-one cases of acute ischemic stroke related to Trousseau syndrome
Authors: Bingqing Zhao
Weihua Jia
Ye Yuan
Zheng Li
Publication date: 13-11-2023
Publisher: Springer International Publishing
Keyword: Stroke
Published in: Neurological Sciences / Issue 4/2024
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-023-07180-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical analysis of twenty-one cases of acute ischemic stroke related to Trousseau syndrome

Abstract

Background

Objective

Methods and material

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Methods and material

Results

Conclusion

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