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Published in:

01-12-2014

Alcoholic Cardiomyopathy: Pathophysiologic Insights

Authors: Mariann R. Piano, Shane A. Phillips

Published in: Cardiovascular Toxicology | Issue 4/2014

Abstract

Alcoholic cardiomyopathy (ACM) is a specific heart muscle disease found in individuals with a history of long-term heavy alcohol consumption. ACM is associated with a number of adverse histological, cellular, and structural changes within the myocardium. Several mechanisms are implicated in mediating the adverse effects of ethanol, including the generation of oxidative stress, apoptotic cell death, impaired mitochondrial bioenergetics/stress, derangements in fatty acid metabolism and transport, and accelerated protein catabolism. In this review, we discuss the evidence for such mechanisms and present the potential importance of drinking patterns, genetic susceptibility, nutritional factors, race, and sex. The purpose of this review is to provide a mechanistic paradigm for future research in the area of ACM.

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Title: Alcoholic Cardiomyopathy: Pathophysiologic Insights
Authors: Mariann R. Piano
Shane A. Phillips
Publication date: 01-12-2014
Publisher: Springer US
Published in: Cardiovascular Toxicology / Issue 4/2014
Print ISSN: 1530-7905
Electronic ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-014-9252-4

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