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Annals of Hematology
Published in: Annals of Hematology 4/2024

31-01-2024 | Acute Promyelocytic Leukemia | Original Article

Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia

Authors: Yue Chen, Mengge Pan, Lanxin Chen, Miaoxin Peng, Zhenyu Liu, Yiran Fang, Ying Du, Yonggong Yang, Peipei Xu

Published in: Annals of Hematology | Issue 4/2024

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Abstract

Acute promyelocytic leukemia (APL) is a specific subtype of acute myeloid leukemia that is distinguished by the chromosomal translocation t(15;17)(q24;q21), which leads to the fusion of the promyelocytic leukemia (PML) gene with the retinoic acid receptor alpha (RARA). Recently, we identified a novel fusion gene in APL, RARA::ankyrin repeat domain 34C (ANKRD34C), identified its functions by morphological, cytogenetic, molecular biological and multiplex fluorescence in situ hybridization analyses, and demonstrated the potential therapeutic effect clinically and experimentally of all-trans retinoic acid (ATRA); the findings have important implications for the diagnosis and treatment of atypical APL.
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Metadata
Title
Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia
Authors
Yue Chen
Mengge Pan
Lanxin Chen
Miaoxin Peng
Zhenyu Liu
Yiran Fang
Ying Du
Yonggong Yang
Peipei Xu
Publication date
31-01-2024
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology / Issue 4/2024
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-024-05629-8

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