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European Journal of Medical Research

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Open Access 01-12-2023 | Acute Pancreatitis | Research

Clinical characteristics and short-term outcomes of acute pancreatitis among patients with COVID-19

Authors: Jinchang Zhang, De Luo, Maoji Kang, Bo Li, Song Su

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

Objective

The existing literature on the combination of acute pancreatitis (AP) and COVID-19 is scarce. The objective of our study is to compare the clinical outcomes and occurrence of long COVID syndrome in AP patients with and without COVID-19, while investigating the potential impact of COVID-19 on the severity, mortality rate, and long COVID syndrome in these patients.

Methods

This retrospective, observational study was conducted at a single center. It included patients aged 18 years and above who were diagnosed with AP during the pandemic. Patients were categorized into two groups based on the results of RT-qPCR testing: the SARS-CoV-2-positive group and the SARS-CoV-2-negative group. The study aimed to compare the severity of AP, mortality rate, and occurrence of long COVID syndrome between these two groups.

Result

A retrospective review was conducted on 122 patients diagnosed with acute pancreatitis between December 1, 2022, and January 31, 2023. Out of these patients, 100 were included in the study. The analysis revealed no significant differences in mortality rate, severity, and sequelae between AP patients with COVID-19 and those without COVID-19 (p > 0.005). However, a statistically significant difference was observed in the occurrence of long COVID syndrome, specifically in the presence of cough (p = 0.04).

Conclusion

This study demonstrates that the presence of COVID-19 in patients with pancreatitis does not lead to an increase in the mortality and severity rate of pancreatitis.

Boxhoorn L, Voermans RP, Bouwense SA, Bruno MJ, Verdonk RC, Boermeester MA, et al. Acute pancreatitis. Lancet. 2020;396(10252):726–34.CrossRefPubMed

Schepers NJ, Bakker OJ, Besselink MG, Ahmed Ali U, Bollen TL, Gooszen HG, et al. Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis. Gut. 2019;68(6):1044–51.CrossRefPubMed

He W, Chen P, Lei Y, Xia L, Liu P, Zhu Y, et al. Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis. Crit Care. 2022;26(1):52.CrossRefPubMedPubMedCentral

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [published correction appears in Lancet. 2020 Jan 30;:]. Lancet. 2020;395(10223):497–506. https://doi.org/10.1016/S0140-6736(20)30183-5

Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, et al. Objective evaluation of anosmia and ageusia in COVID-19 patients: Single-center experience on 72 cases. Head Neck. 2020;42(6):1252–8. https://doi.org/10.1002/hed.26204.CrossRefPubMedPubMedCentral

De Vito A, Geremia N, Fiore V, Princic E, Babudieri S, Madeddu G. Clinical features, laboratory findings and predictors of death in hospitalized patients with COVID-19 in Sardinia. Italy Eur Rev Med Pharmacol Sci. 2020;24(14):7861–8. https://doi.org/10.26355/eurrev_202007_22291.CrossRefPubMed

Guarneri C, Rullo EV, Pavone P, Berretta M, Ceccarelli M, Natale A, et al. Silent COVID-19: what your skin can reveal. Lancet Infect Dis. 2021;21(1):24–5. https://doi.org/10.1016/S1473-3099(20)30402-3.CrossRefPubMed

Guarneri C, VenanziRullo E, Gallizzi R, Ceccarelli M, Cannavò SP, Nunnari G. Diversity of clinical appearance of cutaneous manifestations in the course of COVID-19. J Eur Acad Dermatol Venereol. 2020;34(9):e449–50. https://doi.org/10.1111/jdv.16669.CrossRefPubMedPubMedCentral

Rodriguez-Guerra M, Jadhav P, Vittorio TJ. Current treatment in COVID-19 disease: a rapid review. Drugs Context. 2021. https://doi.org/10.7573/dic.2020-10-3.CrossRefPubMedPubMedCentral

10.

Fiore V, De Vito A, Bagella P, Princic E, Mariani AA, Denti L, et al. Effectiveness of vitamin D supplements among patients hospitalized for COVID-19: results from a monocentric matched-cohort study. Healthcare (Basel). 2022;10(5):956. https://doi.org/10.3390/healthcare10050956.CrossRefPubMed

11.

De Vito A, Poliseno M, Colpani A, Zauli B, Puci MV, Santantonio T, et al. Reduced risk of death in people with SARS-CoV-2 infection treated with remdesivir: a nested case-control study. Curr Med Res Opin. 2022;38(12):2029–33. https://doi.org/10.1080/03007995.2022.2129801.CrossRefPubMed

12.

Hromić-Jahjefendić A, Barh D, Uversky V, Aljabali AA, Tambuwala MM, Alzahrani KJ, et al. Can COVID-19 vaccines induce premature non-communicable diseases: where are we heading to? Vaccines (Basel). 2023;11(2):208.CrossRefPubMed

13.

Fiore V, De Vito A, Fanelli C, Geremia N, Princic E, Nivoli A, et al. Mood reactive disorders among COVID-19 inpatients: experience from a monocentric cohort. Med Princ Pract. 2021;30(6):535–41. https://doi.org/10.1159/000518490.CrossRefPubMedPubMedCentral

14.

Xiong J, Lipsitz O, Nasri F, Lui LMW, Gill H, Phan L, et al. Impact of COVID-19 pandemic on mental health in the general population: a systematic review. J Affect Disord. 2020;277:55–64. https://doi.org/10.1016/j.jad.2020.08.001.CrossRefPubMedPubMedCentral

15.

Gadermann AC, Thomson KC, Richardson CG, Gagné M, McAuliffe C, Hirani S, et al. Examining the impacts of the COVID-19 pandemic on family mental health in Canada: findings from a national cross-sectional study. BMJ Open. 2021;11(1):e042871. https://doi.org/10.1136/bmjopen-2020-042871.CrossRefPubMed

16.

Ma E, Ai J, Zhang Y, Zheng J, Gao X, Xu J, et al. Omicron infections profile and vaccination status among 1881 liver transplant recipients: a multi-centre retrospective cohort. Emerg Microbes Infect. 2022;11(1):2636–44.CrossRefPubMedPubMedCentral

17.

Yang F, Huang Y, Li T, Fu Y, Sun C, Xu Y, et al. Prevalence and outcomes of acute pancreatitis in COVID-19: a meta-analysis. Gut. 2022;71(7):1451–3.CrossRefPubMed

18.

Wang F, Wang H, Fan J, Zhang Y, Wang H, Zhao Q. Pancreatic injury patterns in patients with coronavirus disease 19 pneumonia. Gastroenterology. 2020;159(1):367–70. https://doi.org/10.1053/j.gastro.2020.03.055.CrossRefPubMed

19.

Watson OJ, Barnsley G, Toor J, Hogan AB, Winskill P, Ghani AC. Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infect Dis. 2022;22(9):1293–302.CrossRefPubMedPubMedCentral

20.

Rai P, Kumar BK, Deekshit VK, Karunasagar I, Karunasagar I. Detection technologies and recent developments in the diagnosis of COVID-19 infection. Appl Microbiol Biotechnol. 2021;105(2):441–55.CrossRefPubMedPubMedCentral

21.

Akarsu C, Karabulut M, Aydin H, et al. Association between acute pancreatitis and COVID-19: could pancreatitis be the missing piece of the puzzle about increased mortality rates? J Invest Surg. 2022;35(1):119–25. https://doi.org/10.1080/08941939.2020.1833263.CrossRefPubMed

22.

Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis–2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102–11.CrossRefPubMed

23.

Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.CrossRefPubMed

24.

Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, et al. Post-acute COVID-19 syndrome. Nat Med. 2021;27(4):601–15.CrossRefPubMedPubMedCentral

25.

Wu BU, Johannes RS, Sun X, Tabak Y, Conwell DL, Banks PA. The early prediction of mortality in acute pancreatitis: a large population-based study. Gut. 2008;57(12):1698–703.CrossRefPubMed

26.

Singh VK, Wu BU, Bollen TL, Repas K, Maurer R, Johannes RS, et al. A prospective evaluation of the bedside index for severity in acute pancreatitis score in assessing mortality and intermediate markers of severity in acute pancreatitis. Am J Gastroenterol. 2009;104(4):966–71.CrossRefPubMed

27.

Cheng T, Han TY, Liu BF, Pan P, Lai Q, Yu H, et al. Use of modified balthazar grades for the early prediction of acute pancreatitis severity in the emergency department. Int J Gen Med. 2022;15:1111–9.CrossRefPubMedPubMedCentral

28.

Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med. 1995;23(10):1638–52.CrossRefPubMed

29.

Lai FTT, Yan VKC, Ye X, Ma T, Qin X, Chui CSL, et al. Booster vaccination with inactivated whole-virus or mRNA vaccines and COVID-19-related deaths among people with multimorbidity: a cohort study. CMAJ. 2023;195(4):E143–52.CrossRefPubMedPubMedCentral

30.

Mathieu E, Ritchie H, Ortiz-Ospina E, Roser M, Hasell J, Appel C, et al. A global database of COVID-19 vaccinations. Nat Hum Behav. 2021;5(7):947–53.CrossRefPubMed

31.

Hadi A, Werge M, Kristiansen KT, Pedersen UG, Karstensen JG, Novovic S, et al. Coronavirus Disease-19 (COVID-19) associated with severe acute pancreatitis: case report on three family members. Pancreatology. 2020;20(4):665–7. https://doi.org/10.1016/j.pan.2020.04.021.CrossRefPubMed

32.

Madaria E, Capurso G. COVID-19 and acute pancreatitis: examining the causality. Nat Rev Gastroenterol Hepatol. 2021;18(1):3–4. https://doi.org/10.1038/s41575-020-00389-y.CrossRefPubMed

33.

Brikman S, Denysova V, Menzal H, Dori G. Acute pancreatitis in a 61-year-old man with COVID-19. CMAJ. 2020;192(30):E858–9. https://doi.org/10.1503/cmaj.201029.CrossRefPubMedPubMedCentral

34.

Fiore V, Beretta R, De Vito A, Barac A, Maida I, Joeseph Kelvin DD, et al. Emerging clinical features of COVID-19 related pancreatitis: case reports and review of the literature. Front Med (Lausanne). 2022;8:779118. https://doi.org/10.3389/fmed.2021.779118.CrossRefPubMed

35.

Zheng L, Zhang L, Zheng Y, An J, Wen G, Jin H, et al. Digestive system infection by SARS-CoV-2: entry mechanism, clinical symptoms and expression of major receptors (Review). Int J Mol Med. 2023;51(3):1–11.CrossRef

36.

Liu F, Long X, Zhang B, Zhang W, Chen X, Zhang Z. ACE2 expression in pancreas may cause pancreatic damage after SARS-CoV-2 infection. Clin Gastroenterol Hepatol. 2020;18(9):2128-2130.e2. https://doi.org/10.1016/j.cgh.2020.04.040.CrossRefPubMedPubMedCentral

37.

Lakshmanan S, Malik A. Acute pancreatitis in mild COVID-19 infection. Cureus. 2020;12(8):e9886. https://doi.org/10.7759/cureus.9886.CrossRefPubMedPubMedCentral

38.

Aloysius MM, Thatti A, Gupta A, Sharma N, Bansal P, Goyal H. COVID-19 presenting as acute pancreatitis. Pancreatology. 2020;20(5):1026–7. https://doi.org/10.1016/j.pan.2020.05.003.CrossRefPubMed

39.

Carfì A, Bernabei R, Landi F. Persistent symptoms in patients after acute COVID-19. JAMA. 2020;324(6):603–5.CrossRefPubMedPubMedCentral

40.

Howe S, Szanyi J, Blakely T. The health impact of long COVID during the 2021–2022 Omicron wave in Australia: a quantitative burden of disease study. Int J Epidemiol. 2023;52(3):677–89.CrossRefPubMedPubMedCentral

41.

Richard SA, Pollett SD, Fries AC, Berjohn CM, Maves RC, Lalani T, et al. Persistent COVID-19 symptoms at 6 months after onset and the role of vaccination before or after SARS-CoV-2 infection. JAMA Netw Open. 2023;6(1): e2251360.CrossRefPubMedPubMedCentral

Title: Clinical characteristics and short-term outcomes of acute pancreatitis among patients with COVID-19
Authors: Jinchang Zhang
De Luo
Maoji Kang
Bo Li
Song Su
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Acute Pancreatitis
COVID-19
SARS-CoV-2
Long-COVID Syndrome
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-023-01252-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical characteristics and short-term outcomes of acute pancreatitis among patients with COVID-19

Abstract

Objective

Methods

Result

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Result

Conclusion

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