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European Journal of Medical Research

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Open Access 01-12-2023 | Septicemia | Research

Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates

Authors: Junfei Guo, Weiming Lai, Yongbing Wu, Huan Li, Zhenhua Fu, Xiaoping Mu

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

Background

Changes of serum lipoprotein concentration during bacteremia or sepsis are observed and lipoproteins concentration facilitate the evaluation severity of sepsis in adults, but its clinical usage is still unclear. Here, we analyzed the lipoprotein concentration in neonates with sepsis and discussed its use in stratifying patients.

Methods

This is a retrospective study involved 88 culture-proven septic patients. Clinical and microbiology data of involved patients were collected via inquiring databases of our institute. Patients were grouped according to blood culture results or procalcitonin level; the difference between groups were analyzed.

Results

Compared with uninfected group, there is no change of triglyceride (TG) concentrations and significant decrease of Total cholesterol (TC) concentration in septic patients. There is no significant difference between Gram-positive and Gram-negative-related septic patients in terms of serum TG and TC concentration. Other than group with procalcitonin level of 0.5–2 ng/ml, both serum TG and TC concentration were decreased while serum procalcitonin level increasing.

Conclusions

Our results indicated that serum lipoprotein concentration may be recommended to help diagnosis of bacteria and to evaluate the severity of sepsis.

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Title: Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates
Authors: Junfei Guo
Weiming Lai
Yongbing Wu
Huan Li
Zhenhua Fu
Xiaoping Mu
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Septicemia
Septicemia
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-023-01077-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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