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Lasers in Medical Science
Published in: Lasers in Medical Science 7/2021

01-09-2021 | Actinic Keratosis | Review Article

The application of physical pretreatment in photodynamic therapy for skin diseases

Authors: Dihui Liu, Shuang Zhao, Jinmao Li, Mingliang Chen, Lisha Wu

Published in: Lasers in Medical Science | Issue 7/2021

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Abstract

Photodynamic therapy (PDT) is widely used in skin diseases; the response rate of PDT treatment varies widely. The limited penetration in the tissue of photosensitizers influenced the penetration depth of PDT, which obviously impacts the therapeutic effect. The studies have improved the efficacy of PDT through various pretreatment applications; especially, the physical pretreatment had achieved significant outcomes. We will review the physical pretreatment to optimize the efficacy of PDT in skin diseases by searching the literature on this topic. The types of physical pretreatment commonly used in the clinical practice are discussed: curettage, superficial shaving, laser, surgical resection, plum-blossom needles, and microneedles. Compared with PDT alone, the physical pretreatment before PDT application was generally improved the efficacy and reduced the recurrence, especially in actinic keratoses (AK), Bowen disease (BD), basal cell carcinoma (BCC), and viral warts. The application of the physical pretreatments before PDT may improve the efficacy of PDT in various skin diseases. However, each kind of physical pretreatment has the benefit and shortcoming, and the applicable situation is different.
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Metadata
Title
The application of physical pretreatment in photodynamic therapy for skin diseases
Authors
Dihui Liu
Shuang Zhao
Jinmao Li
Mingliang Chen
Lisha Wu
Publication date
01-09-2021
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 7/2021
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-020-03233-6

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