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646 search results for:

vulvar intraepithelial neoplasia 

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  1. Open Access 01-08-2021 | vulvar intraepithelial neoplasia | OriginalPaper

    Histological interpretation of differentiated vulvar intraepithelial neoplasia (dVIN) remains challenging—observations from a bi-national ring-study

    Differentiated vulvar intraepithelial neoplasia (dVIN) is a premalignant lesion that is known to progress rapidly to invasive carcinoma. Accurate histological diagnosis is therefore crucial to allow appropriate treatment. To identify reliable …

  2. 01-03-2019 | vulvar intraepithelial neoplasia | OriginalPaper

    Sec62/Ki67 and p16/Ki67 dual-staining immunocytochemistry in vulvar cytology for the identification of vulvar intraepithelial neoplasia and vulvar cancer: a pilot study

    Vulvar cancer is the fourth most common gynecological malignancy in the United States after uterine, ovarian and cervical cancers [ 1 ]. Squamous cell carcinoma (SCC) is the most common histological subtype [ 2 – 4 ]. Other less common histologies …

  3. 01-05-2019 | Human Papillomavirus | BriefCommunication

    Modified Turnbull–Cutait anastomosis with fasciocutaneous flap reconstruction for radical excision of vulvar and anal intraepithelial neoplasia

    Intraepithelial neoplasia of the lower genital tract, perineum and perianal area is most often linked to the prevalence of human papillomavirus (HPV) infection [ 1 ]. HPV predisposes to precancerous lesions involving the cervix, but less commonly …

  4. Open Access 01-12-2018 | OriginalPaper

    Differentiated vulvar intraepithelial neoplasia (dVIN): the most helpful histological features and the utility of cytokeratins 13 and 17

    Differentiated vulvar intraepithelial neoplasia (dVIN) is the precursor lesion of HPV-negative vulvar squamous cell carcinoma (VSCC). The histopathological diagnosis of dVIN can be challenging, as it often resembles vulvar non-neoplastic …

  5. 01-10-2017 | OriginalPaper

    Papillomavirus genotyping on formaldehyde fixed paraffin-embedded tissues in vulvar intraepithelial neoplasia

    Vulvar intraepithelial neoplasia (VIN) denotes precancerous lesions of the vulva. Most often, it arises due to human papillomavirus (HPV) infection and is referred to as “usual VIN”. On the other hand, “differentiated VIN” is associated with …

  6. 01-11-2018 | OriginalPaper

    Impact of re-excision of residual adjacent vulvar intraepithelial neoplasia (VIN III) and histological tumour-free margin (hTFM) on survival in primary squamous cell carcinoma of vulva

    Vulvar cancer is a rare condition accounting for 5% of all gynecological malignancies, but its incidence has been doubled in the last decade [ 1 ]. Because of its association with human papillomavirus (HPV) the incidence increases approximately …

  7. 01-09-2017 | OriginalPaper

    HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia

    Vulvar intraepithelial neoplasia (VIN) is a premalignant chronic skin disorder of the vulva epithelium. VIN lesions were reclassified in 2004 by the International Society for the Study of Vulvovaginal Disease as usual type VIN (uVIN), formerly …

  8. 01-06-2016 | Report

    Extra-Genital Bowen’s Disease on Abdomen Co-existing with Vulvar Intraepithelial Neoplasia

    Bowen’s disease was first described by the American dermatologist Dr. John T Bowen in 1912 as a form of intra-epidermal squamous cell carcinoma in situ of the genital region [ 1 ]. However, the International Society for Study of Vulvar Disease …

  9. 01-02-2009 | OriginalPaper

    A cluster of vulvar cancer and vulvar intraepithelial neoplasia in young Australian Indigenous women

    Cancer of the vulva is a rare malignancy. In 1993–1997, the age-adjusted incidence rate ranged from 0.1 to 2.7 per 100,000 women in countries throughout the world [ 1 ]; the total Australian incidence rate was 1.4 per 100,000 women, with an average …

  10. 01-07-2002 | OriginalPaper

    The pathology and molecular biology of anal intraepithelial neoplasia: comparisons with cervical and vulvar intraepithelial carcinoma

    Background: Anal intraepithelial neoplasia (AIN) is a well-described pathological precursor of invasive squamous cell carcinoma which has recently been detected with increasing frequency in immunocompromised patients, particularly those with …

  11. Open Access 01-12-2011 | OriginalPaper

    Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study

    Invasive vulvar squamous cell carcinomas (VSCC) represent the fourth most common type of malignant tumor of the female genital tract in the United States, with an estimated 3, 580 new cases and 900 deaths in 2009 [ 1 ]. Recently, a significant …

  12. 01-03-2007 | OriginalPaper

    Detection and identification of human papiliomavirus in vulvar intraepithelial neoplasia

  13. Open Access 01-12-2011 | OriginalPaper

    Economic burden of vulvar and vaginal intraepithelial neoplasia: retrospective cost study at a German dysplasia centre

    Human papillomavirus (HPV) is responsible for a variety of diseases [ 1 – 3 ]. Discussion concerning HPV and associated epidemiology and disease burden, treatment and vaccination focuses predominantly on cervical cancer and cervical intraepithelial

  14. 01-10-2011 | OriginalPaper

    A case of usual (basaloid)-type vulvar intraepithelial neoplasia that failed to respond to imiquimod cream: clinical implications

    The authors report a case of usual-type (basaloid-type) vulvar intraepithelial neoplasia (VIN) 3 that failed to respond to imiquimod cream. A 51-year-old Japanese woman visited her local gynecologist complaining of vulvar itching. Atypical cells …

  15. 01-09-2006 | OriginalPaper

    Immunohistochemical expression of p16 and p53 in vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva

    This study was undertaken to examine the expression of p16 and p53 in vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma (SCC) of the vulva. We also analyzed the relationship between p16 and p53 immunoexpression in women younger …

  16. Open Access 08-04-2024 | Human Papillomavirus | ReviewPaper

    Structured Literature Review to Identify Human Papillomavirus’s Natural History Parameters for Dynamic Population Models of Vaccine Impacts

    Human papillomavirus (HPV) is a common sexually transmitted virus that can cause cervical cancer and other diseases. Dynamic transmission models (DTMs) have been developed to evaluate the health and economic impacts of HPV vaccination. These …

  17. 06-05-2024 | Gynecologic Cancer | Online First

    The challenge of survivors of gynecological carcinomas: a retrospective study on occurrence of second tumors

    Gynecologic cancer seriously endangers women’s health, and the incidence rate of endometrial cancer and ovarian cancer is increasing [ 1 ]. Although HPV vaccine can effectively prevent cervical cancer, the incidence rate of cervical cancer is still …

  18. Open Access 14-05-2024 | Hysterectomy | Online First

    Comprehensive evaluation of vaginal intraepithelial neoplasia development after hysterectomy: insights into diagnosis and treatment strategies

    Vaginal intraepithelial neoplasia (VaIN), a precancerous lesion associated with human papillomavirus (HPV), impacts women’s health and quality of life. However, the natural progression of VaIN after hysterectomy remains uncertain, due to its low …

  19. Open Access 29-04-2024 | Human Papillomavirus | Online First

    Comparing the effects of argon plasma coagulation and interferon therapy in patients with vaginal intraepithelial neoplasia: a single-center retrospective study

    Vaginal intraepithelial neoplasia (VaIN) is defined as atypical hyperplasia of different levels limited to the vaginal intraepithelial tissue. VaIN is precancerous lesion that could potentially lead to vaginal carcinoma. In 1952, Graham and Meigs …

  20. Open Access 01-12-2024 | Human Papillomavirus | OriginalPaper

    Clinical characteristics, HPV involvement, and demographic risk factors in women with cervical intraepithelial neoplasia complicated by vaginal intraepithelial neoplasia

    Vaginal intraepithelial neoplasia (VAIN) represents a precancerous condition of the vagina, characterized by epithelial dysplasia and carcinoma in situ without invasion beyond the basal membrane [ 1 ]. This condition, largely attributed to human …

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