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01-09-2021 | Original Article

Photobiomodulation by a new optical fiber device: analysis of the in vitro impact on proliferation/migration of keratinocytes and squamous cell carcinomas cells stressed by X-rays

Authors: Elodie Courtois, Jean-Baptiste Guy, Fabrice Axisa, Pierre Saint-Girons, Laure Alston, Narimène Houmera, René-Jean Bensadoun, Anne Visbecq, Claire Rodriguez-Lafrasse, Nicolas Magné

Published in: Lasers in Medical Science | Issue 7/2021

Abstract

Photobiomodulation-based (PBM-based) therapies show promising results in mucositis and dermatitis treatment by stimulating wound healing mechanisms such as cell proliferation and migration. The aim of the present study is to investigate the in vitro effects of CareMin650 on the proliferation and migration of two different types of cells, namely cancer and non-cancer cells, with or without X-ray radiation. Study design used PBM through a combination of 0-3-6 J/cm² doses—with or without X-ray radiation—on the proliferation and migration capabilities of a keratinocyte cell line (HaCaT) and a squamous cell carcinoma line (SCC61). PBM is delivered by a new woven optical fiber device, namely CareMin650 prototype (light emission by LEDs (light-emitting diodes), peak at 660 nm, irradiance of 21.6 mW/cm²). The effectiveness of PBM to increase HaCaT proliferation and migration (with or without X-ray radiation) supports the capability of PBM to favor wound healing. It also highlights that PBM does not provide any anti-radiation effect to previously X-rays radiated SCC (p < 0.001). Such data supports the beneficial effect of PBM delivered by an optical fiber device to heal wounds, without promoting cancer development.

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Title: Photobiomodulation by a new optical fiber device: analysis of the in vitro impact on proliferation/migration of keratinocytes and squamous cell carcinomas cells stressed by X-rays
Authors: Elodie Courtois
Jean-Baptiste Guy
Fabrice Axisa
Pierre Saint-Girons
Laure Alston
Narimène Houmera
René-Jean Bensadoun
Anne Visbecq
Claire Rodriguez-Lafrasse
Nicolas Magné
Publication date: 01-09-2021
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 7/2021
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-020-03185-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Photobiomodulation by a new optical fiber device: analysis of the in vitro impact on proliferation/migration of keratinocytes and squamous cell carcinomas cells stressed by X-rays

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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