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Open Access 01-12-2019 | Whooping Cough | Commentary

Comment on the trial protocol “Early versus late BCG vaccination in HIV-1-exposed infants in Uganda: study protocol for a randomized controlled trial”

Authors: Sanne Marie Thysen, Ane Bærent Fisker

Published in: Trials | Issue 1/2019

Excerpt

We have read with interest the study protocol by Nankabirwa et al. [1]. The authors propose a study of the non-specific effects (NSEs) of Bacillus Calmette-Guérin (BCG) vaccine in HIV-1-exposed children. Children will be randomised to BCG at birth or at 14 weeks of age. Follow-up for the main outcome is planned from 0 to 14 weeks. …

Nankabirwa V, Tumwine JK, Namugga O, et al. Early versus late BCG vaccination in HIV-1-exposed infants in Uganda: study protocol for a randomized controlled trial. Trials. 2017;18(1):152.CrossRef

Higgins JP, Soares-Weiser K, Lopez-Lopez JA, et al. Association of BCG, DTP, and measles containing vaccines with childhood mortality: systematic review. BMJ. 2016;355:i5170.CrossRef

Aaby P, Ravn H, Benn CS. The WHO review of the possible non-specific effects of diphtheria-tetanus-pertussis vaccine. Pediatr Infect Dis J. 2016;35(11):1247–57.CrossRef

Aaby P, Ravn H, Fisker AB, Rodrigues A, Benn CS. Is diphtheria-tetanus-pertussis (DTP) associated with increased female mortality? A meta-analysis testing the hypotheses of sex-differential non-specific effects of DTP vaccine. Trans R Soc Trop Med Hyg. 2016;110(10):570–81.CrossRef

Benn CS, Sorup S. Commentary: BCG has no beneficial non-specific effects on Greenland. An answer to the wrong question? Int J Epidemiol. 2016;45(6):2131–3.PubMedPubMedCentral

Biering-Sørensen S, Aaby P, Lund N, et al. Early BCG-Denmark and neonatal mortality among infants weighing < 2500 g: a randomized controlled trial. Clin Infect Dis. 2017;65(7):1183–90.CrossRef

Title: Comment on the trial protocol “Early versus late BCG vaccination in HIV-1-exposed infants in Uganda: study protocol for a randomized controlled trial”
Authors: Sanne Marie Thysen
Ane Bærent Fisker
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Whooping Cough
Vaccination
Human Immunodeficiency Virus
Tetanus
Diphtheria
Published in: Trials / Issue 1/2019
Electronic ISSN: 1745-6215
DOI: https://doi.org/10.1186/s13063-019-3213-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comment on the trial protocol “Early versus late BCG vaccination in HIV-1-exposed infants in Uganda: study protocol for a randomized controlled trial”

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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