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Virology Journal
Published in: Virology Journal 1/2021

01-12-2021 | Vulgar Psoriasis | Research

Is there a relationship between psoriasis and hepatitis C? A meta-analysis and bioinformatics investigation

Authors: Yong Liu, Sheng Nan Cui, Meng Yao Duan, Zhi Li Dou, Yi Zhen Li, Yi Xing Liu, Ye Xia, Jia Wei Zhang, Xiao Ning Yan, Dong Ran Han

Published in: Virology Journal | Issue 1/2021

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Abstract

Background

The relationship between psoriasis and hepatitis C was previously controversial, so our purpose is to investigate this connection.

Methods

We conducted a systematic review of the case–control, cross-sectional and cohort studies examining the association between psoriasis and hepatitis C in PubMed, EMBASE and Cochrane library databases and investigated the overlapping genes between psoriasis targets and hepatitis C targets using bioinformatics analysis. Based on overlapping genes and hub nodes, we also constructed the protein–protein interaction (PPI) network and module respectively, followed by the pathway enrichment analysis.

Results

We included 11 publications that reported a total of 11 studies (8 cross-sectional and 3 case–control). The case–control and cross-sectional studies included 25,047 psoriasis patients and 4,091,631 controls in total. Psoriasis was associated with a significant increase of prevalent hepatitis C (OR 1.72; 95% confidence interval [CI] (1.17–2.52)). A total of 389 significant genes were common to both hepatitis C and psoriasis, which mainly involved IL6, TNF, IL10, ALB, STAT3 and CXCL8. The module and pathway enrichment analyses showed that the common genes had the potential to influence varieties of biological pathways, including the inflammatory response, cytokine activity, cytokine–cytokine receptor interaction, Toll-like receptor signaling pathway, which play an important role in the pathogenesis of hepatitis C and psoriasis.

Conclusion

Patients with psoriasis display increased prevalence of hepatitis C and the basic related mechanisms between hepatitis C and psoriasis had been preliminarily clarified.
Appendix
Available only for authorised users
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Metadata
Title
Is there a relationship between psoriasis and hepatitis C? A meta-analysis and bioinformatics investigation
Authors
Yong Liu
Sheng Nan Cui
Meng Yao Duan
Zhi Li Dou
Yi Zhen Li
Yi Xing Liu
Ye Xia
Jia Wei Zhang
Xiao Ning Yan
Dong Ran Han
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2021
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-021-01606-z

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