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Systematic Reviews
Published in: Systematic Reviews 1/2021

Open Access 01-12-2021 | Systematic review update

Vitamin D status and blood pressure in children and adolescents: a systematic review of observational studies

Authors: Myriam Abboud, Fatme Al Anouti, Dimitrios Papandreou, Rana Rizk, Nadine Mahboub, Suzan Haidar

Published in: Systematic Reviews | Issue 1/2021

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Abstract

Background

Childhood hypertension is a growing public health problem. Simultaneously, hypovitaminosis D is widespread in this population and could be associated with hypertension. This study systematically reviewed the literature on the relationship between vitamin D status and blood pressure (BP) in children and adolescents.

Methods

Following the PRISMA guidelines, PUBMED, MEDLINE, CINAHL, EMBASE, Cochrane Library, and ClinicalTrials.​gov and the gray literature without language or time restrictions were searched. We included observational studies, assessed their risk of bias, and extracted data on population characteristics, vitamin D status and BP measurements, and the association between the two variables. A narrative analysis of the studies was performed.

Results

In total, 85 studies were included. Prospective cohort studies showed no association between vitamin D and BP, and generally, they were flawed. Also, the majority of non-prospective cohort studies (cross-sectional, retrospective, case-control) did not report an association between vitamin D and BP. They were mostly flawed regarding BP measurement and adjusting to potential confounders.

Conclusion

The results on the relationship between vitamin D status and BP in children and adolescents varied between the studies, and mainly pointed towards lack of association.
Appendix
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Metadata
Title
Vitamin D status and blood pressure in children and adolescents: a systematic review of observational studies
Authors
Myriam Abboud
Fatme Al Anouti
Dimitrios Papandreou
Rana Rizk
Nadine Mahboub
Suzan Haidar
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2021
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-021-01584-x

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