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Seminoma 

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  1. 22-11-2023 | Seminoma | OriginalPaper

    Overexpression of SerpinB9 in non-seminomatous germ cell tumors

    Serpinb9 is an inhibitor of granzyme B and is potentially involved in the immune escape of tumor cells. In the present study, bioinformatics analysis using open databases suggested that SerpinB9 is overexpressed in testicular embryonal carcinoma.

  2. 29-02-2024 | Hypogonadism | Online First

    Cumulative incidences of hypogonadism, hypertension, and dyslipidaemia in patients with stage I seminoma treated with a risk-adapted strategy: a Spanish single-centre retrospective analysis

    Stage 1 seminoma (S1S) is a testicular cancer (TC) diagnosed in young adult men, and it is highly curable with orchiectomy alone. However, tumour size > 4 cm and rete testis involvement have been identified as independent risk factors for …

  3. Open Access 01-12-2024 | Chondrosarcoma | OriginalPaper

    SMARCB1-Deficient Skull Base Chondrosarcoma with 12p Duplication Presenting as Somatic-Type Malignancy Arising from Metastatic Seminoma

    Somatic-type malignancy (STM) can occur infrequently within a primary or metastatic testicular germ cell tumor (TGCT) and is associated with dismal prognosis and survival. STM with chondrosarcomatous features is exceedingly rare and head and neck …

  4. 18-11-2023 | Seminoma | OriginalPaper

    Advances in radiation therapy for testicular seminoma

    Radiation therapy (RT) is a well-established treatment for early-stage testicular seminoma due to its radiosensitive histology [ 1 ], and has been successfully used to treat seminoma patients since at least the 1920s [ 2 ]. Serologic and …

  5. Open Access 01-12-2023 | Seminoma | OriginalPaper

    Seminoma arising in splenogonadal fusion: a case report and literature review

    Splenogonadal fusion (SGF) is a rare congenital malformation characterized by an abnormal connection between the splenic tissue and gonadal-mesonephric structures [ 1 ]. It was first described in 1883 by Bostroem [ 2 ]. In 1956, Putschar and Manion …

  6. Open Access 14-12-2023 | Seminoma | Online First

    Molecular and histopathological characterization of seminoma patients with highly elevated human chorionic gonadotropin levels in the serum

    Approximately 30% of seminoma (SEM) patients present with moderately elevated human chorionic gonadotropin (hCG) levels at first diagnosis. In case of high hCG serum levels, the presence of a non-SEM component, i.e. choriocarcinoma (CC), may be …

  7. 03-07-2023 | Dyspnea | Online First

    Quality of life assessment in testicular non-seminomatous germ cell tumour survivors

    Germ cell tumour(GCT) commonly affects men between the ages of 20–40 years, contributing to 1–3% of all cancers occurring in men [ 32 ]. Advances in the management of testicular cancer in the last thirty years have resulted in excellent long-term …

  8. Open Access 01-12-2023 | Seminoma | OriginalPaper

    Analysis of connexin 43, connexin 45 and N-cadherin in the human sertoli cell line FS1 and the human seminoma-like cell line TCam-2 in comparison with human testicular biopsies

    Testicular tumors are the most common malignant tumors in men between 15 and 40 years and the incidence is rising [ 1 , 2 ]. Germ cell tumors (GCTs) are of particular importance, of which seminoma accounts for about 50% [ 3 ]. Seminomas, as well as …

  9. Open Access 01-12-2022 | Seminoma | OriginalPaper

    Chemoradiotherapy is an alternative choice for patients with primary mediastinal seminoma

    Primary mediastinal germ-cell neoplasms are rare neoplasms. Mediastinal seminoma accounts for approximately 10–16% of mediastinal germ-cell neoplasms and 0.5–5% of all mediastinal tumors [ 1 , 2 ]. This low incidence has precluded the development …

  10. Open Access 01-12-2022 | Seminoma | OriginalPaper

    Two decades of FDG-PET/CT in seminoma: exploring its role in diagnosis, surveillance and follow-up

    Testicular cancer is curable in most individuals, regardless of histologic subtype, disease stage or primary site, owing to significant advances in treatment [ 1 ]. However, there is growing evidence that survivors experience significant long-term …

  11. 20-02-2023 | Surgery | OriginalPaper

    Postchemotherapy robotic retroperitoneal lymph node dissection for non-seminomatous germ cell tumors in the lateral decubitus position: oncological and functional outcomes

    Cisplatin-based chemotherapy is highly effective as the first-line treatment for metastatic non-seminomatous germ cell tumors (NSGCT), but up to 40% of patients demonstrate residual retroperitoneal mass [ 1 ]. RPLND is mandated in all patients with …

  12. 01-02-2022 | Seminoma | OriginalPaper

    Clinical stage II seminoma: management options

    Seminoma of the testicle is the most common solid tumor in men presenting in the third and fourth decades of life. Approximately, 15–20% present with clinical stage II (CS-II) disease, which is characterized by pure seminoma in the orchiectomy …

  13. 17-05-2023 | Seminoma | OriginalPaper

    A case of testicular seminoma with testicular abscess caused by Salmonella saintpaul

    Testicular abscesses are rarer than epididymitis and orchitis. Here, we report a case of testicular seminoma with testicular abscess caused by Salmonella saintpaul. A 41-year-old male was referred for painful enlargement of the right scrotal …

  14. 23-06-2023 | Seminoma | OriginalPaper

    Outcomes of surveillance versus adjuvant treatment for patients with stage-I seminoma: a single-center experience

    Testicular cancer is the most common solid malignancy affecting males between the ages of 15 and 35, although it accounts for only one percent of all cancers in males [ 1 ] They are categorized into two forms: pure seminoma and non-seminoma [ 2 ].

  15. Open Access 01-12-2023 | Seminoma | OriginalPaper

    Mediastinal high-grade vasculogenic mesenchymal tumour with seminoma: a case report and literature review

    Germ cell tumours with somatic-type solid malignancy (GCT-STM) are a rare disease of the mediastinum. Recently, a cohort of vasculogenic mesenchymal tumour (VMT)-nonseminoma cases with different prognoses were recognized and reported. Here, we …

  16. Open Access 15-11-2021 | Seminoma | OriginalPaper

    Therapy of clinical stage IIA and IIB seminoma: a systematic review

    Testicular cancer (TC) is the most common solid malignancy in young men [ 1 , 2 ]. Accounting for only 7% of all TC patients, clinical stage (CS) IIA/B seminoma, defined as disease spread to the retroperitoneal lymph nodes of up to 2 cm (CS IIA) or …

  17. Open Access 01-06-2021 | Seminoma | BriefCommunication

    Seminoma Retroperitoneal Relapse 23 Years After Surgery

    Stage I seminoma is the most frequent tumour in young men. It has a very good prognosis thanks to the use of a multidisciplinary therapeutic approach including surgery, radiotherapy and systemic chemotherapy. Late (after 2 years) and very late …

  18. 01-12-2021 | Seminoma | Case Study

    An incidental finding of testicular seminoma in the context of acute pulmonary embolism: a case report

    Cancer is a well-established risk factor for venous thromboembolism (VTE) and, specifically, pulmonary embolism (PE). Studies have shown that 4–9% of patients diagnosed with apparently unprovoked VTE receive a cancer diagnosis within 12 months [ 1 …

  19. Open Access 19-06-2023 | OriginalPaper

    Comparison of laparoscopic, robotic, and open retroperitoneal lymph node dissection for non-seminomatous germ cell tumor: a single-center retrospective cohort study

    Among all kinds of malignancies, testicular cancer is relatively rare and less lethal. Despite of its rarity and high survival rate, it is the most common solid tumor in male population between 20 and 34 years. Because of their contribution to …

  20. 01-05-2021 | Seminoma | Letter

    Clonal derivation of sequential seminoma and acute megakaryoblastic leukaemia

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