While active angiogenesis is known to be a prerequisite for tumor growth beyond a few mm3 in size, lymphangiogenesis in normal or pathological adult tissues, including malignant tumors has not been reported. If lymphangiogenesis takes place during cancer progression, cancers with active lymphangiogenesis could be predisposed to metastatic spread via the lymphatic system and thus to poor survival. …
Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.