Tumorigenesis is a multistep process involving the acquisition of genetic mutations which override events controlling normal proliferation. The cumulative effects eventually lead to anchorage-independent growth and survival in the absence of growth factors. Although normal rodent cells can be made tumorigenic in vitro, attempts to achieve the same with human cells have been unsuccessful. …
Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.