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Clinical Rheumatology
Published in: Clinical Rheumatology 6/2019

01-06-2019 | Vasculitis | Case Based Review

Exceptional association of hypocomplementemic urticarial vasculitis syndrome (HUVS) and symptomatic pulmonary histoplasmosis: a case-based literature review

Authors: Mohammad Alomari, Laith Al Momani, Shrouq Khazaaleh, Shaden Almomani, Kinanah Yaseen, Bassam Alhaddad

Published in: Clinical Rheumatology | Issue 6/2019

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Abstract

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare type III hypersensitivity disorder characterized by urticarial vasculitis and prolonged hypocomplementemia. Individuals with HUVS may also have joint involvement, pulmonary manifestations, ocular disease, kidney inflammation, or any other form of organ involvement. Hypocomplementemia, the presence of C1q antibody in the serum, and urticarial vasculitis are the keys to the diagnosis of HUVS. It has been reported to accompany certain infections such as hepatitis B, hepatitis C, infectious mononucleosis, and coxsackie group A. However, it has never been reported to be linked to histoplasmosis in the literature. To the best of our knowledge, we report the first case of HUVS presenting concurrently with pulmonary histoplasmosis.
Literature
1.
McDuffie F, Sams J, Maldonado J, Andreini P, Conn D, Samayoa E (1973) Hypocomplementemia with cutaneous vasculitis and arthritis. Possible immune complex syndrome. Mayo Clin Proc 48:340–348PubMed
2.
Sturgess A, Littlejohn G (1988) Jaccoud’s arthritis and panvasculitis in the hypocomplementemic urticarial vasculitis syndrome. J Rheumatol 15:858–861PubMed
3.
Grimbert P, Scholte K, Buisson C, Desvaux D, Baron C, Pastural M (2001) Renal transplantation in a patient with hypocomplementemic urticarial vasculitis syndrome. Am J Kidney Dis 37:144–148CrossRefPubMed
4.
Zeiss C, Burch F, Marder R, Furey N, Schmid F, Gewurz H (1980) A hypocomplementemic vasculitic urticarial syndrome. Report of four new cases and definition of the disease. Am J Med 68:687–695CrossRef
5.
Aydogan K, Karadogan S, Adim S, Tunali S (2006) Hypocomplementemic urticarial vasculitis: a rare presentation of systemic lupus erythematosus. Int J Dermatol 45(9):1057–1061CrossRefPubMed
6.
Wisnieski J, Baer A, Christensen J et al (1995) Hypocomplementemic urticarial vasculitis syndrome. Clinical and serological findings in 18 patients. Medicine 74:24–41CrossRefPubMed
7.
Jamison S, Brierre S, Sweet J, de Boisblanc B (2008) A case of precocious emphysema and lung cancer in a woman with a history of hypocomplementemic urticarial vasculitis. Chest 133(3):787–789CrossRefPubMed
8.
Grotz W, Baba H, Becker J, Baumgärtel M (2009) Hypocomplementemic urticarial vasculitis syndrome. An interdisciplinary challenge. Dtsch Arztebl Int 106(46):756–763PubMedPubMedCentral
9.
10.
11.
Hammerman K, Powell K, Tosh F (1974) The incidence of hospitalized cases of systemic mycotic infections. Sabouraudia 12:33–45CrossRefPubMed
12.
Calvo-Romero JM, Diffuse Large B (2003) Cell lymphoma in a patient with hypocomplementemic urticarial vasculitis. J Postgrad Med 49:252–253PubMed
13.
Assi M, Sandid M, Baddour L, Roberts G, Walker R (2007) Systemic histoplasmosis: a 15-year retrospective institutional review of 111 patients. Medicine (Baltimore) 86:162–169CrossRef
14.
Moresi J (2004) Neutrophilic dermatoses. AJSP Rev Rep 9(2):46–54
15.
16.
17.
Daves M, Daoud M, Kirby B, Gibson LE, Rogers RS 3rd. (1998) Clinicopathologic correlation of hypocomplementemic and normocomplementemic urticarial vasculitis. J Am Acad Dermatol 38:899–905
18.
Mehregan D, Hall M, Gibson L (1992) Urticarial vasculitis? A histopathological and clinical review of 72 cases. J Am Acad Dermatol 26:441–448CrossRefPubMed
19.
Jara L, Navarro C, Medina G, Vera-Lastra O, Saavedra MA (2009) Hypocomplementemic urticarial vasculitis syndrome. Curr Rheumatol Rep 11:410–415CrossRefPubMed
20.
Wisnieski J, Jones S (1992) IgG autoantibody to the collagen-like region of C1q in hypocomplementemic urticarial vasculitis syndrome, systemic lupus erythematosus, and 6 other musculoskeletal or rheumatic diseases. J Rheumatol 19:884–888PubMed
21.
22.
Buck A, Christensen J, Mc Carty M (2012) Hypocomplementemic urticarial vasculitis syndrome: a case report and literature review. J Clin Aesthet Dermatol 5:36–46PubMedPubMedCentral
23.
Schwartz HR, Mc Duffie FC, Black LF, Schroeter AL, Conn DL (1982) Hypocomplementemic urticarial vasculitis: association with chronic obstructive pulmonary disease. Mayo Clin Proc 57:231–238PubMed
24.
Hawkins P, Lachmann H, Aganna E, McDermott M (2004) Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum 50(2):607–612CrossRefPubMed
25.
26.
McNeil D, Kinsella T, Crawford A, Fritzler M (1987) The AHA syndrome: arthritis, hives and angioedema. Rheumatol Int 7(6):277–279CrossRefPubMed
27.
Callen J, Kalbfeisch S (1982) Urticarial vasculitis. Report of 9 cases and review of the literature. Br J Dermatol 107:87–93CrossRefPubMed
28.
29.
Curd J, Zuraw B (1984) Efficacy of hydroxychloroquine treatment of urticarial vasculitis. J Allergy Clin Immunol 73:181
30.
Sanchez N, Winkelmann R, Schroeter A, Dicken CH (1982) The clinical and histopathologic spectrums of urticarial vasculitis: study of forty cases. J Am Acad Dermatol 7:599–605CrossRefPubMed
Metadata
Title
Exceptional association of hypocomplementemic urticarial vasculitis syndrome (HUVS) and symptomatic pulmonary histoplasmosis: a case-based literature review
Authors
Mohammad Alomari
Laith Al Momani
Shrouq Khazaaleh
Shaden Almomani
Kinanah Yaseen
Bassam Alhaddad
Publication date
01-06-2019
Publisher
Springer London
Published in
Clinical Rheumatology / Issue 6/2019
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-019-04548-8

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