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BMC Cardiovascular Disorders
Published in: BMC Cardiovascular Disorders 1/2016

Open Access 01-12-2016 | Research article

Vascular structure and function and their relationship with health-related quality of life in the MARK study

Authors: Luis García-Ortiz, José I. Recio-Rodríguez, Sara Mora-Simón, John Guillaumet, Ruth Martí, Cristina Agudo-Conde, Emiliano Rodriguez-Sanchez, Jose A. Maderuelo-Fernandez, Rafel Ramos-Blanes, Manuel A. Gómez-Marcos, the MARK Group

Published in: BMC Cardiovascular Disorders | Issue 1/2016

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Abstract

Background

There is limited evidence concerning the relationship between vascular disease and health-related quality of life (HRQL). We investigated the relationship between vascular structure and function with health-related quality of life in a population with intermediate cardiovascular risk.

Methods

This study analyzed 303 subjects with ankle-brachial index (ABI) values ranging from 0.9 to 1.4 who were included in the MARK study (age 35 to 74 years; mean:60.5 ± 8.5), of which 50.2 % were women. Measurements included: ABI, brachial-ankle pulse wave velocity (ba-PWV), and cardio-ankle vascular index (CAVI), all measured using the VaSera device. The central augmentation index was adjusted to 75 lpm (AIx_75) using the Mobil-O-Graph device. HRQL was assessed by the Spanish version of the SF-12, version2. The highest obtained CAVI and ba-PWV values and the lowest ABI values were considered for the study.

Results

The cohort was composed of21 % smokers, 76 % hypertensive patients, and 24 % diabetic patients. The ABI mean was 1.09 ± 0.07,the ba-PWV mean was 14.64 ± 2.55 m/s with a 12.9 % of subjects higher than 17.5 m/s, AIx_75 26.46 ± 14.05, and CAVI 8.61 ± 1.08 with a 36.6 % of subjects higher than 9. Men scored higher than women in the HRQL measurements for physical (PSC-12; 49.9 vs. 46.9, p = 0.004) and mental (MSC-12) domains (51.2 vs. 47.7, p = 0.003). Age was positively correlated with CAVI (r = 0.547), ba-PWV (r = 0.469), AIx_75 (r = 0.255, p < 0.01), and the MSC-12 (r = 0.147, p < 0.05), but not the PSC-12. In the adjusted multiple linear regression analysis, the positive association of ABI and CAVI with the PSC-12 was maintained.

Conclusions

The ABI in the normal range has a positive association with the PSC-12 of HRQL evaluated with the SF-12. The CAVI also showed a positive association with the PSC-12 of HRQL.

Trial Registration

ClinicalTrials.gov Identifier: NCT01428934.
Appendix
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Metadata
Title
Vascular structure and function and their relationship with health-related quality of life in the MARK study
Authors
Luis García-Ortiz
José I. Recio-Rodríguez
Sara Mora-Simón
John Guillaumet
Ruth Martí
Cristina Agudo-Conde
Emiliano Rodriguez-Sanchez
Jose A. Maderuelo-Fernandez
Rafel Ramos-Blanes
Manuel A. Gómez-Marcos
the MARK Group
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2016
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-016-0272-9

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