Top

Published in:

Open Access 01-05-2021 | Vaccination | Research Letter

The disproportionate excess mortality risk of COVID-19 in younger people with diabetes warrants vaccination prioritisation

Authors: Andrew P. McGovern, Nick J. Thomas, Sebastian J. Vollmer, Andrew T. Hattersley, Bilal A. Mateen, John M. Dennis

Published in: Diabetologia | Issue 5/2021

Excerpt

To the Editor: Diabetes has consistently been shown to independently increase the risk of poor coronavirus disease-2019 (COVID-19) outcomes [1‐3]. Rather than a simple additive effect of diabetes and age-related risk, recent large studies suggest a more complex relationship, with a disproportionately higher excess relative mortality risk in younger people with diabetes compared with older people with diabetes [1, 3, 4]. Better understanding of the interaction between age and diabetes in the context of COVID-19 will further inform the complex prioritisation decisions around COVID-19 vaccination [5]. …

Available only for authorised users

Williamson EJ, Walker AJ, Bhaskaran K et al (2020) Factors associated with COVID-19-related death using OpenSAFELY. Nature 584(7821):430–436. https://doi.org/10.1038/s41586-020-2521-4CrossRefPubMedPubMedCentral

Barron E, Bakhai C, Kar P et al (2020) Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study. Lancet Diabetes Endocrinol 8(10):813–822. https://doi.org/10.1016/S2213-8587(20)30272-2CrossRefPubMedPubMedCentral

Dennis JM, Mateen BA, Sonabend R et al (2020) Type 2 diabetes and COVID-19-related mortality in the critical care setting: a national cohort study in England, March–July 2020. Diabetes Care 44(1):50–57. https://doi.org/10.2337/dc20-1444

Clift AK, Coupland CAC, Keogh RH et al (2020) Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study. BMJ 371:m3731. https://doi.org/10.1136/bmj.m3731CrossRefPubMed

The Lancet Diabetes & Endocrinology (2021) Coronavirus vaccine? Join the queue. Lancet Diabetes Endocrinol 9(1):1. https://doi.org/10.1016/S2213-8587(20)30409-5CrossRef

Spiegelhalter D (2020) Use of “normal” risk to improve understanding of dangers of covid-19. BMJ 370:m3259. https://doi.org/10.1136/bmj.m3259CrossRefPubMed

Spiegelhalter D (2016) How old are you, really? Communicating chronic risk through ‘effective age’ of your body and organs. BMC Med Inform Decis Mak 16(1):104. https://doi.org/10.1186/s12911-016-0342-zCrossRefPubMedPubMedCentral

Holman N, Knighton P, Kar P et al (2020) Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study. Lancet Diabetes Endocrinol 8(10):823–833. https://doi.org/10.1016/S2213-8587(20)30271-0CrossRefPubMedPubMedCentral

Cariou B, Hadjadj S, Wargny M et al (2020) Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia 63(8):1500–1515. https://doi.org/10.1007/s00125-020-05180-xCrossRefPubMedPubMedCentral

10.

McGurnaghan SJ, Weir A, Bishop J et al (2021) Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland. Lancet Diabetes Endocrinol 9(2):82–93. https://doi.org/10.1016/S2213-8587(20)30405-8CrossRefPubMed

11.

Public Health England (2021) COVID-19 vaccination first phase priority groups. Available from: www.gov.uk/government/publications/covid-19-vaccination-care-home-and-healthcare-settings-posters/covid-19-vaccination-first-phase-priority-groups. Accessed: 6 January 2021

12.

Centers for Disease Control and Prevention (2021) When Vaccine is Limited, Who Should Get Vaccinated First? Available from: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations.html. Accessed: 6 January 2021

Title: The disproportionate excess mortality risk of COVID-19 in younger people with diabetes warrants vaccination prioritisation
Authors: Andrew P. McGovern
Nick J. Thomas
Sebastian J. Vollmer
Andrew T. Hattersley
Bilal A. Mateen
John M. Dennis
Publication date: 01-05-2021
Publisher: Springer Berlin Heidelberg
Keywords: Vaccination
COVID-19
Published in: Diabetologia / Issue 5/2021
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-021-05404-8

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits

STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 5/2021

Retinal venular tortuosity and fractal dimension predict incident retinopathy in adults with type 2 diabetes: the Edinburgh Type 2 Diabetes Study

Realising the long-term promise of insulin therapy: the DCCT/EDIC study

Hypothalamic glucose-sensing mechanisms

Potential diabetes overtreatment and risk of adverse events among older adults in Ontario: a population-based study

Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial

‘Smart’ insulin-delivery technologies and intrinsic glucose-responsive insulin analogues

Highlights from the ACC 2024 Congress

ACC 2024 Congress Coverage