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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 8/2019

01-08-2019 | Uveitis | Inflammatory Disorders

Comparison of clinical characteristics in patients with Vogt-Koyanagi-Harada disease with and without anti-retinal antibodies

Authors: Yuki Hashimoto, Wataru Saito, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Kousuke Noda, Atsuhiro Kanda, Susumu Ishida

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 8/2019

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Abstract

Purpose

To compare the clinical characteristics of Vogt-Koyanagi-Harada (VKH) disease patients with and without anti-retinal antibodies (ARAs) that are frequently detected in autoimmune retinopathy.

Methods

Using immunoblot analyses, serum autoantibodies for recoverin, carbonic anhydrase II, and α-enolase were examined in 20 treatment-naïve patients with VKH disease. Clinical factors before and after systemic corticosteroid therapy, including best-corrected visual acuity (BCVA) and macular outer retinal morphology, were statistically compared between patients with VKH disease with and without ARAs.

Results

Serum ARAs were detected in 50.0% of patients with VKH disease. There were no significant differences in clinical factors between the two groups, including final BCVA, frequency of uveitis recurrence, and recovery of the macular ellipsoid zone after systemic corticosteroid therapy.

Conclusions

Our results suggest that the detected ARAs did not influence visual outcomes, the chronicity of uveitis, or outer retinal morphology in patients with VKH disease.
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Metadata
Title
Comparison of clinical characteristics in patients with Vogt-Koyanagi-Harada disease with and without anti-retinal antibodies
Authors
Yuki Hashimoto
Wataru Saito
Kenichi Namba
Kazuomi Mizuuchi
Daiju Iwata
Kousuke Noda
Atsuhiro Kanda
Susumu Ishida
Publication date
01-08-2019
Publisher
Springer Berlin Heidelberg
Keyword
Uveitis
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 8/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-019-04330-1

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