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International Ophthalmology
Published in: International Ophthalmology 2-3/2007

01-06-2007 | Original Paper

Pathology of Vogt–Koyanagi–Harada disease

Author: Narsing A. Rao

Published in: International Ophthalmology | Issue 2-3/2007

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Abstract

Typical histopathologic features of Vogt–Koyanagi–Harada disease (VKH) include granulomatous panuveitis with preservation of the choriocapillaris and exudative retinal detachment. In the chronic stage of the disease, however, histologic changes consist of nongranulomatous uveitis followed, in the chronic recurrent stage, by granulomatous uveitis and involvement of the choriocapillaris. In chronic VKH the peripheral fundus scars are not Dalén–Fuchs nodules; they are, instead, indicative of focal chorioretinal atrophy with loss of retinal pigment epithelium.
Literature
1.
Inomata H, Rao NA (2001) Depigmented atrophic lesions in sunset glow fundi of Vogt–Koyangi–Harada disease. Am J Ophthalmol 131:607–614PubMedCrossRef
2.
Rao NA, Xu S, Font RL (1985) Sympathetic Ophthalmia. An immunohistochemical study of epithelioid and giant cells. Ophthalmology 92:1660–1662PubMed
3.
Font RL, Fine BS, Messmer E, Rawley JF (1983) Light and electron microscopic study of Dalén–Fuchs nodules in sympathetic ophthalmia. Ophthalmology 90:66–75PubMed
4.
Jakobiec FA, Marboe CC, Knowles DM II, Iwamoto T, Harrison W, Chang S, et al (1983) Human sympathetic ophthalmia. An analysis of the inflammatory infiltrate by hybridoma-monoclonal antibodies, immunochemistry, and correlative electron microscopy. Ophthalmology 90:76–95PubMed
5.
Sakamoto T, Murata T, Inomata H (1991) Class II major histocompatibility complex on melanocytes of Vogt–Koyanagi–Harada disease. Arch Ophthalmol 109:1270–1274PubMed
6.
Inomata H, Sakamoto T (1990) Immunohistochemical studies of Vogt–Koyanagi–Harada disease with sunset sky fundus. Curr Eye Res 9(Suppl):35–40PubMed
7.
Yamaki K, Gocho K, Hayakawa K, Kondo I, Sakuragi S (2000) Tyrosinase family proteins are antigen specific to Vogt–Koyanagi–Harada disease. J Immunol 165:7323–9PubMed
8.
Moorthy RS, Inomata H, Rao NA (1995) Vogt–Koyanagi–Harada syndrome. Surv Ophthalmol 39:265–292PubMedCrossRef
9.
Perry HD, Font RL (1977) Clinical and histopathologic observations in severe Vogt–Koyanagi–Harada syndrome. Am J Ophthalmol 83:242–254PubMed
Metadata
Title
Pathology of Vogt–Koyanagi–Harada disease
Author
Narsing A. Rao
Publication date
01-06-2007
Publisher
Kluwer Academic Publishers
Published in
International Ophthalmology / Issue 2-3/2007
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-006-9029-2

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