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International Ophthalmology
Published in: International Ophthalmology 2-3/2007

01-06-2007 | Original Paper

Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease

Authors: Sunao Sugita, Hiroshi Takase, Tatsushi Kawaguchi, Chikako Taguchi, Manabu Mochizuki

Published in: International Ophthalmology | Issue 2-3/2007

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Abstract

Aim To determine whether T lymphocytes of patients with Vogt–Koyanagi–Harada (VKH) disease cross-react with peptides of melanocytes and with exogenous antigens.
Methods Cross-reactivity with melanocyte peptides, tyrosinase (tyrosinase450–462: SYLQDSDPDSFQD) and the mimic virus peptide, i.e., cytomegalovirus envelope glycoprotein H (CMV-egH290–302: SYLKDSDFLDAAL) was examined by a lymphocyte proliferation assay or cytokine production. The seroprevalence of various viruses was examined by a complement fixation test. To examine if the virus infections in VKH patients were latent, we measured genomic DNA of the virus using real-time polymerase chain reaction (PCR). Result Some of the T cells established from VKH recognized melanocyte peptides including the tyrosinase peptide as well as the CMV-egH290–302 peptide, which had a high amino acid homology to the tyrosinase peptide. Cytomegalovirus (CMV) peptide-specific T cells showed a significant proliferation not only to CMV-egH290–302 but also to tyrosinase450–462. The seroprevalence of CMV was significantly higher in VKH patients. In addition, all tested samples of VKH patients were negative for CMV-DNA.
Conclusions These results indicate that CMV infection may stimulate the production of T cells that cross-react with tyrosinase by a mechanism of molecular mimicry. These events may be responsible for the onset of VKH disease.
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Metadata
Title
Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease
Authors
Sunao Sugita
Hiroshi Takase
Tatsushi Kawaguchi
Chikako Taguchi
Manabu Mochizuki
Publication date
01-06-2007
Publisher
Kluwer Academic Publishers
Published in
International Ophthalmology / Issue 2-3/2007
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-006-9020-y

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