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Fluids and Barriers of the CNS
Published in: Fluids and Barriers of the CNS 1/2012

Open Access 01-12-2012 | Short paper

Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands

Authors: Sven Jarius, Peter Eichhorn, Brigitte Wildemann, Manfred Wick

Published in: Fluids and Barriers of the CNS | Issue 1/2012

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Abstract

Background

Testing for cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCB) by isoelectric focusing is used to detect intrathecally produced total IgG. By contrast, antibody indices (AI) are assessed to test for intrathecally produced antigen-specific IgG. A number of previous cases reports have suggested that AI testing might be more sensitive than OCB testing in detecting intrathecal IgG synthesis.

Findings

Here we report on 21 patients with positive AI for either herpes simplex virus, varicella zoster virus, cytomegalovirus, measles virus, rubella virus, or Borrelia burgdorferi in the absence of total-IgG OCB and, accordingly, in the presence of a normal total-IgG CSF/serum ratio.

Conclusion

Our findings indicate that AI testing should not generally be omitted in OCB-negative patients and provide a rationale for systematic and prospective studies on the comparative sensitivity and specificity of AI and total-IgG OCB testing in infectious and other diseases of the CNS.
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Metadata
Title
Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands
Authors
Sven Jarius
Peter Eichhorn
Brigitte Wildemann
Manfred Wick
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Fluids and Barriers of the CNS / Issue 1/2012
Electronic ISSN: 2045-8118
DOI
https://doi.org/10.1186/2045-8118-9-14

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