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Fluids and Barriers of the CNS

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Open Access 01-12-2005 | Research

Expansion of antibody reactivity in the cerebrospinal fluid of multiple sclerosis patients – follow-up and clinical implications

Authors: Hela-Felicitas Petereit, Dirk Reske

Published in: Fluids and Barriers of the CNS | Issue 1/2005

Abstract

Background

An intrathecal polyspecific antibody response is a well known finding in multiple sclerosis. However, little is known about the evolution of intrathecal antibodies over time and their impact on the disease progress. Therefore, we focused in this study on the intrathecal polyspecific antibody response in multiple sclerosis.

Methods

Here we present a follow-up study of 70 patients with multiple sclerosis over 1 to 106 months. Serum and cerebrospinal fluid sample pairs were obtained from 1 to 5 consecutive lumbar punctures. CSF cell count, the IgG index, local IgG synthesis, oligoclonal bands and the antibody index for measles, rubella or varicella zoster were calculated. Results were analysed with regard to clinical characteristics of the patients.

Results

Once an intrathecal antibody response was established, it persisted. De novo antibody response against measles virus developed in 7% of the patients between the first and the second spinal tap. In two of seven patients where 5 consecutive CSF samples were available, the intrathecal antibody response expanded from one to three antigens. Furthermore, an intrathecal measles antibody production was associated with a rapid progression of the disease.

Conclusion

These data stress the importance of activated B cells for the disease process and the clinical outcome in multiple sclerosis.

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Title: Expansion of antibody reactivity in the cerebrospinal fluid of multiple sclerosis patients – follow-up and clinical implications
Authors: Hela-Felicitas Petereit
Dirk Reske
Publication date: 01-12-2005
Publisher: BioMed Central
Published in: Fluids and Barriers of the CNS / Issue 1/2005
Electronic ISSN: 2045-8118
DOI: https://doi.org/10.1186/1743-8454-2-3

At a glance: The STEP trials

Springer Medicine

Expansion of antibody reactivity in the cerebrospinal fluid of multiple sclerosis patients – follow-up and clinical implications

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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