Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Endocrine
Published in: Endocrine 3/2019

01-12-2019 | Ultrasound | Research Letter

An unusual epididymal localization of Testicular Adrenal Rest Tumor in an adolescent with congenital adrenal hyperplasia

Authors: Domenico Corica, Antonio Bottari, Tommaso Aversa, Danilo Caudo, Karol Galletta, Martina Francesca Micalizzi, Giovanni Battista Pajno, Malgorzata Wasniewska, Giorgio Ascenti

Published in: Endocrine | Issue 3/2019

Login to get access

Excerpt

Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder, affecting adrenal cortex steroid synthesis, caused by 21β-hydroxylase (21-OH) deficiency in more than 90% of the cases [1]. The specific mutation of CYP21 gene determines the degree of impairment of 21-OH activity and different phenotypes of CAH: salt-wasting (SW), simple virilizing (SV) and late onset (LO). …
Literature
1.
H.L. Claahsen-van der Grinten, A.R. Hermus, B.J. Otten, Testicular adrenal rest tumours in congenital adrenal hyperplasia. Int. J. Pediatr. Endocrinol. 2009, 624823 (2009)CrossRef
2.
H. Falhammar, H.F. Nystrom, U. Ekstrom, S. Granberg, A. Wedell, M. Thoren, Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia. Eur. J. Endocrinol. 166, 441–449 (2012)CrossRef
3.
D. Corica, S. Santucci, E. Pitrolo, M. Romeo, M. Wasniewska, F. De Luca, Testicular adrenal rest tumor in an adolescent with congenital adrenal hyperplasia, resolved by therapy doses adjustment. Minerva Pediatr. 66, 233–235 (2014)PubMed
4.
H.L. Claahsen-van der Grinten, F.C. Sweep, J.G. Blickman, A.R. Hermus, B.J. Otten, Prevalence of testicular adrenal rest tumors in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Eur. J. Endocrinol. 157, 339–344 (2007)CrossRef
5.
E.D. Cakir, F.S. Mutlu, E. Eren, A.O. Paşa, H. Sağlam, O. Tarim, Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia. J. Clin. Res. Pediatr. Endocrinol. 4, 94–100 (2012)CrossRef
6.
H.L. Claahsen-van der Grinten, B.J. Otten, F.C. Sweep, P.N. Span, H.A. Ross, E.J. Meuleman et al. Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue. J. Clin. Endocrinol. Metab. 92, 3674–3680 (2007)CrossRef
7.
Z. Wang, Z. Yang, W. Wang, L.D. Chen, Y. Huang, W. Li et al. Diagnosis of testicular adrenal rest tumors on ultrasound: a retrospective study of 15 cases report. Medicine 94, e1471 (2015)CrossRef
8.
S.S. Deshpande, D. Shetty, S. Saifi, Sonographic appearance of testicular adrenal rest tumour in a patient with congenital adrenal hyperplasia. Pol. J. Radiol. 82, 526–529 (2017)CrossRef
9.
Z. Aycan, V.N. Bas, S. Cetinkaya, S. Yilmaz Agladioglu, T. Tiryaki, Prevalence and long-term follow-up outcomes of testicular adrenal rest tumours in children and adolescent males with congenital adrenal hyperplasia. Clin. Endocrinol. 78, 667–672 (2013)CrossRef
10.
N.M. Stikkelbroeck, H.M. Suliman, B.J. Otten, A.R. Hermus, J.G. Blickman, G.J. Jager, Testicular adrenal rest tumours in postpubertal males with congenital adrenal hyperplasia: sonographic and MR features. Eur. Radiol. 13, 1597–1603 (2003)CrossRef
11.
N.A. Avila, T.S. Shawker, J.V. Jones, G.B. Cutler Jr, D.P. Merke, Testicular adrenal rest tissue in congenital adrenal hyperplasia: serial sonographic and clinical findings. AJR Am. J. Roentgenol. 172, 1235–1238 (1999)CrossRef
12.
D. Lee, S.K. Rodgers, Testicular adrenal rests. Ultrasound Q. 24, 105–107 (2008)CrossRef
13.
N.A. Avila, A. Premkumar, T.H. Shawker, J.V. Jones, L. Laue, G.B. Cutler Jr., Testicular adrenal rest tissue in congenital adrenal hyperplasia: findings at Gray-scale and color Doppler US. Radiology 198, 99–104 (1996)CrossRef
14.
T. Auer, T. De Zordo, C. Dejaco, L. Gruber, R. Pichler, W. Jaschke et al. Value of multiparametric US in the assessment of intratesticular lesions. Radiology 285, 640–649 (2017)CrossRef
15.
C. Cicero, M. Bertolotto, B.R. Hawthorn, C. Trambaiolo Antonelli, P.S. Sidhu, G. Ascenti et al. Multiple, synchronous lesions of differing histology within the same testis: ultrasonographic and pathologic correlations. Urology 121, 125–131 (2018)CrossRef
16.
D.Y. Huang, P.S. Sidhu, Focal testicular lesions: colour Doppler ultrasound, contrast-enhanced ultrasound and tissue elastography as adjuvants to the diagnosis. Br. J. Radiol. 85, S41–S53 (2012). Spec No 1CrossRef
17.
C. Pozza, D. Gianfrilli, G. Fattorini, E. Giannetta, F. Barbagallo, E. Nicolai et al. Diagnostic value of qualitative and strain ratio elastography in the differential diagnosis of non-palpable testicular lesions. Andrology 4, 1193–1203 (2016)CrossRef
18.
P.S. Sidhu, Multiparametric ultrasound (MPUS) imaging: terminology describing the many aspects of ultrasonography. Ultraschall Med. 36, 315–317 (2015)CrossRef
19.
G. Jedrzejewski, I. Ben-Skowronek, M.M. Wozniak, A. Brodzisz, E. Budzynska, A.P. Wieczorek, Testicular adrenal rest tumors in boys with congenital adrenal hyperplasia: 3D US and elastography–do we get more information for diagnosis and monitoring? J. Pediatr. Urol. 9, 1032–1037 (2013)CrossRef
20.
L. Manganaro, V. Vinci, C. Pozza, M. Saldari, D. Gianfrilli, R. Pofi et al. A prospective study on contrast-enhanced magnetic resonance imaging of testicular lesions: distinctive features of Leydig cell tumours. Eur. Radiol. 25, 3586–3595 (2015)CrossRef
21.
L. Manganaro, M. Saldari, C. Pozza, V. Vinci, D. Gianfrilli, E. Greco et al. Dynamic contrast-enhanced and diffusion-weighted MR imaging in the characterisation of small, non-palpable solid testicular tumours. Eur. Radiol. 28, 554–564 (2018)CrossRef
22.
R. Yılmaz, D. Şahin, A. Aghayev, O.B. Erol, Ş. Poyrazoğlu, N. Saka et al. Sonography and magnetic resonance imaging characteristics of testicular adrenal rest tumors. Pol. J. Radiol. 82, 583–588 (2017)CrossRef
Metadata
Title
An unusual epididymal localization of Testicular Adrenal Rest Tumor in an adolescent with congenital adrenal hyperplasia
Authors
Domenico Corica
Antonio Bottari
Tommaso Aversa
Danilo Caudo
Karol Galletta
Martina Francesca Micalizzi
Giovanni Battista Pajno
Malgorzata Wasniewska
Giorgio Ascenti
Publication date
01-12-2019
Publisher
Springer US
Published in
Endocrine / Issue 3/2019
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-019-01986-x

Other articles of this Issue 3/2019

Endocrine 3/2019 Go to the issue

Original Article

Body muscle-to-fat ratio gender-specific cut-off values for impaired insulin sensitivity in patients with treatment-naïve type 2 diabetes mellitus

Editorial

Medicine in the era of network science

Original Article

Ultrasound combined with biochemical parameters can predict parathyroid carcinoma in patients with primary hyperparathyroidism

Original Article

Identification of gene co-expression modules and hub genes associated with lymph node metastasis of papillary thyroid cancer

Correction

Correction to: Thyroid hormone therapy: past, present, and future

Original Article

Common genetic variations of deiodinase genes and prognosis of brain tumor patients
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits