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Chinese Medicine
Published in: Chinese Medicine 1/2019

Open Access 01-12-2019 | Ulcerative Colitis | Review

Novel drug delivery systems of Chinese medicine for the treatment of inflammatory bowel disease

Authors: Caifang Gao, Lijuan Liu, Yangyang Zhou, Zhaoxiang Bian, Shengpeng Wang, Yitao Wang

Published in: Chinese Medicine | Issue 1/2019

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Abstract

Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease that comprises ulcerative colitis (UC) and Crohn’s disease (CD). IBD involves the ileum, rectum, and colon, and common clinical manifestations of IBD are diarrhea, abdominal pain, and even bloody stools. Currently, non-steroidal anti-inflammatory drugs, glucocorticoids, and immunosuppressive agents are used for the treatment of IBD, while their clinical application is severely limited due to unwanted side effects. Chinese medicine (CM) is appealing more and more attention and investigation for the treatment of IBD owing to the potent anti-inflammation pharmacological efficacy and high acceptance by patients. In recent years, novel drug delivery systems are introduced apace to encapsulate CM and many CM-derived active constituents in order to improve solubility, stability and targeting ability. In this review, advanced drug delivery systems developed in the past and present to deliver CM for the treatment of IBD are summarized and future directions are discussed.
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Metadata
Title
Novel drug delivery systems of Chinese medicine for the treatment of inflammatory bowel disease
Authors
Caifang Gao
Lijuan Liu
Yangyang Zhou
Zhaoxiang Bian
Shengpeng Wang
Yitao Wang
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Chinese Medicine / Issue 1/2019
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/s13020-019-0245-x

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