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Diabetology & Metabolic Syndrome

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Open Access 01-12-2024 | Type 2 Diabetes | Research

The association between plasma free amino acids and type 2 diabetes mellitus complicated with infection in Chinese patients

Authors: Jing-Xi Zhang, Wei-Ming Luo, Bo-Wen Wang, Ru-Tao Li, Qian Zhang, Xiang-Yu Zhang, Zhong-Ze Fang, Zhi-Peng Zhang

Published in: Diabetology & Metabolic Syndrome | Issue 1/2024

Abstract

Background

Type 2 diabetes mellitus (T2DM), one of the most common public diseases threatening human health, is always accompanied by infection. Though there are still a variety of flaws in the treatment of some infectious diseases, metabolomics provides a fresh perspective to explore the relationship between T2DM and infection. Our research aimed to investigate the association between plasma free amino acids (PFAAs) and T2DM complicated with infection in Chinese patients.

Methods

A cross-sectional study was conducted from May 2015 to August 2016. We retrieved the medical records of 1032 inpatients with T2DM from Liaoning Medical University First Affiliated Hospital and we used mass spectrometry to quantify 23 PFAAs. Infections contained 15 individual categories that could be retrieved from the database. Principal component analysis was used to extract factors of PFAAs. Multi-variable binary logistic regression was used to obtain odds ratios (OR) and their 95% confidence intervals (CI).

Results

Among 1032 inpatients,109 (10.6%) had infectious diseases. Six factors, accounting for 68.6% of the total variance, were extracted. Factor 4 consisted of Glu, Asp and Orn. Factor 5 consisted of Hcy and Pip. After adjusting for potential confounders, factor 4 was positively correlated with T2DM complicated with infection in Chinese T2DM patients (OR: 1.27, 95%CI: 1.06–1.52). Individual Hcy in factor 5 was positively associated with T2DM complicated with infection (OR: 1.33, 95%CI: 1.08–1.64). Furthermore, factor 4 (OR: 1.44, 95%CI: 1.11–1.87), Orn (OR: 1.01, 95%CI: 1.00-1.02) and Hcy (OR: 1.56, 95%CI: 1.14–3.14) were positively associated with bacterial infection in Chinese T2DM patients, while factor 5 (OR: 0.71, 95%CI: 0.50-1.00) was negatively associated with bacterial infection.

Conclusions

Urea cycle-related metabolites (Orn, Asp, Glu) and Hcy were positively associated with T2DM complicated with infection in China. Orn and Hcy were positively associated with bacterial infection in T2DM patients in China.

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Title: The association between plasma free amino acids and type 2 diabetes mellitus complicated with infection in Chinese patients
Authors: Jing-Xi Zhang
Wei-Ming Luo
Bo-Wen Wang
Ru-Tao Li
Qian Zhang
Xiang-Yu Zhang
Zhong-Ze Fang
Zhi-Peng Zhang
Publication date: 01-12-2024
Publisher: BioMed Central
Keyword: Type 2 Diabetes
Published in: Diabetology & Metabolic Syndrome / Issue 1/2024
Electronic ISSN: 1758-5996
DOI: https://doi.org/10.1186/s13098-023-01203-w

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