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03-01-2021 | Tuberculosis | Letter to the Editor

Development of high signal intensity within the globus pallidus and dentate nucleus following multiple administrations of gadoterate meglumine in a patient with neurotuberculosis

Authors: Bahar Cankaya, Yasemin Ogul, Hayri Ogul, Mecit Kantarci

Published in: Acta Neurologica Belgica | Issue 3/2022

Excerpt

Since 1988, when gadolinium-based contrast agents (GBCAs) have been approved by the Food and Drug Administration (FDA). At that time, those have been considered extremely safe pharmaceutical agents [1]. However, in the early 2000s, research has shown that unstable forms of GBCAs cause nephrogenic systemic fibrosis in patients with poor renal function [2]. This has led to the questioning of the safety of GBCAs, and over time, it has been proven that linear GBCAs accumulate in deep cerebellar nuclei depending on concentration [3, 4]. …

Robert P, Lehericy S, Grand S et al (2015) T1-weighted hypersignal in the deep cerebellar nuclei after repeated administrations of gadolinium-based contrast agents in healthy rats: difference between linear and macrocyclic agents. Invest Radiol 50:473–480CrossRefPubMedPubMedCentral

Kanda T, Ishii K, Kawaguchi H, Kitajima K, Takenaka D (2014) High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology 270:834–841CrossRefPubMed

Kanda T, Osawa M, Oba H, Toyoda K, Kotoku J, Haruyama T, Takeshita K, Furui S (2015) High signal intensity in dentate nucleus on unenhanced T1-weighted MR images: association with linear versus macrocyclic gadolinium chelate administration. Radiology 275:803–809CrossRefPubMed

Radbruch A, Weberling LD, Kieslich PJ, Eidel O, Burth S, Kickingereder P, Heiland S, Wick W, Schlemmer HP, Bendszus M (2015) Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent. Radiology 275:783–791CrossRefPubMed

Radbruch A, Haase R, Kieslich PJ, Weberling LD, Kickingereder P, Wick W, Schlemmer HP, Bendszus M (2017) No signal intensity increase in the dentate nucleus on unenhanced T1-weighted MR images after more than 20 serial injections of macrocyclic gadolinium-based contrast agents. Radiology 282:699–707CrossRefPubMed

Title: Development of high signal intensity within the globus pallidus and dentate nucleus following multiple administrations of gadoterate meglumine in a patient with neurotuberculosis
Authors: Bahar Cankaya
Yasemin Ogul
Hayri Ogul
Mecit Kantarci
Publication date: 03-01-2021
Publisher: Springer International Publishing
Keywords: Tuberculosis
Tuberculosis
Neurotuberculosis
Published in: Acta Neurologica Belgica / Issue 3/2022
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-020-01561-6

At a glance: The STEP trials

Springer Medicine

Development of high signal intensity within the globus pallidus and dentate nucleus following multiple administrations of gadoterate meglumine in a patient with neurotuberculosis

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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