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BMC Infectious Diseases

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Open Access 01-12-2021 | Tuberculosis | Case report

Adenosine deaminase negative pleural tuberculosis: a case report

Authors: Zachary H. Boggs, Scott Heysell, Joshua Eby, Christopher Arnold

Published in: BMC Infectious Diseases | Issue 1/2021

Abstract

Background

A pleural fluid adenosine deaminase (ADA) has been used globally to assist in the diagnosis of a tuberculous pleural effusion (TPE) with a notable negative predictive value.

Case presentation

We report a case of a patient with a negative pleural fluid ADA who was found to have culture-positive and biopsy-proven Mycobacterium tuberculosis.

Conclusions

This case shows the importance of pursuing gold standard diagnostic studies when clinical suspicion remains high despite negative preliminary testing. We further describe gaps in research to improve pleural fluid biomarkers for TPE.

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Title: Adenosine deaminase negative pleural tuberculosis: a case report
Authors: Zachary H. Boggs
Scott Heysell
Joshua Eby
Christopher Arnold
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Tuberculosis
Mycobacterium Tuberculosis
Pleural Effusion
Tuberculosis
Published in: BMC Infectious Diseases / Issue 1/2021
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-021-06276-4

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Abstract

Background

Case presentation

Conclusions

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