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Published in: Clinical and Translational Medicine 1/2017

Open Access 01-12-2017 | Perspective

Translational research in pediatric pulmonary disease, 2017

Author: Bruce K. Rubin

Published in: Clinical and Translational Medicine | Issue 1/2017

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Abstract

As readers of this journal know, translational research is the application of basic science findings to improve clinical care; a process that was once called “bench-to-bedside” research. In my field of pediatric pulmonary disease, the rapid advancement of basic science understanding into improved clinical care has been, to use an appropriate term, breathtaking. In this perspective article, I will describe a few of these advances, as they relate to specific pulmonary diseases.
Literature
1.
go back to reference Ramsey BW, Davies J, McElvaney NG et al (2011) A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. N Engl J Med 365:1663–1672CrossRefPubMedPubMedCentral Ramsey BW, Davies J, McElvaney NG et al (2011) A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. N Engl J Med 365:1663–1672CrossRefPubMedPubMedCentral
2.
go back to reference Wainwright CE, Elborn JS, Ramsey BW, TRAFFIC Study Group, TRANSPORT Study Group et al (2015) Lumacaftor-ivacaftor in patients with cystic fibrosis homozygous for Phe508del CFTR. N Engl J Med 373:220–231CrossRefPubMedPubMedCentral Wainwright CE, Elborn JS, Ramsey BW, TRAFFIC Study Group, TRANSPORT Study Group et al (2015) Lumacaftor-ivacaftor in patients with cystic fibrosis homozygous for Phe508del CFTR. N Engl J Med 373:220–231CrossRefPubMedPubMedCentral
4.
go back to reference Durack J, Lynch SV, Nariya S et al (2017) Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. doi:10.1016/j.jaci.2016.08.055 (in press) Durack J, Lynch SV, Nariya S et al (2017) Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. doi:10.​1016/​j.​jaci.​2016.​08.​055 (in press)
5.
go back to reference Finkel RS, Flanigan KM, Wong B et al (2013) Phase 2a study of ataluren-mediated dystrophin production in patients with nonsense mutation Duchenne muscular dystrophy. PLoS ONE 8:e81302CrossRefPubMedPubMedCentral Finkel RS, Flanigan KM, Wong B et al (2013) Phase 2a study of ataluren-mediated dystrophin production in patients with nonsense mutation Duchenne muscular dystrophy. PLoS ONE 8:e81302CrossRefPubMedPubMedCentral
7.
go back to reference Dori Y, Keller MS, Fogel MA et al (2014) MRI of lymphatic abnormalities after functional single-ventricle palliation surgery. AJR Am J Roentgenol 203:426–431CrossRefPubMed Dori Y, Keller MS, Fogel MA et al (2014) MRI of lymphatic abnormalities after functional single-ventricle palliation surgery. AJR Am J Roentgenol 203:426–431CrossRefPubMed
8.
go back to reference Deutsch GH, Young LR, Deterding RR et al (2007) Diffuse lung disease in young children. Application of a novel classification scheme. Am J Respir Crit Care Med 176:1120–1128CrossRefPubMedPubMedCentral Deutsch GH, Young LR, Deterding RR et al (2007) Diffuse lung disease in young children. Application of a novel classification scheme. Am J Respir Crit Care Med 176:1120–1128CrossRefPubMedPubMedCentral
Metadata
Title
Translational research in pediatric pulmonary disease, 2017
Author
Bruce K. Rubin
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical and Translational Medicine / Issue 1/2017
Electronic ISSN: 2001-1326
DOI
https://doi.org/10.1186/s40169-017-0142-9

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