Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Lasers in Medical Science
Published in: Lasers in Medical Science 8/2019

01-10-2019 | Original Article

Transcutaneous transmission of photobiomodulation light to the spinal canal of dog as measured from cadaver dogs using a multi-channel intra-spinal probe

Authors: Daqing Piao, Lara A. Sypniewski, Danielle Dugat, Christian Bailey, Daniel J. Burba, Luis DeTaboada

Published in: Lasers in Medical Science | Issue 8/2019

Login to get access

Abstract

The target level photobiomodulation (PBM) irradiances along the thoracic to lumbar segment of the interior spinal canal in six cadaver dogs resulting from surface illumination at 980 nm were measured. Following a lateral hemi-laminectomy, a flexible probe fabricated on a plastic tubular substrate of 6.325 mm diameter incorporating nine miniature photodetectors was embedded in the thoracic to lumbar segment of the spinal canal. Intra-spinal irradiances at the nine photodetector sites, spanning an approximate 8 cm length caudal to T13, were measured for various applied powers of continuous wave (CW) surface illumination at 980 nm with a maximal power of 10 W corresponding to a surface irradiance of 3.14 W/cm2. The surface illumination conditions differed in skin transmission when the probe was off-contact with tissue and probe-skin contact when the skin was in place. For each condition of surface illumination, the beam was directed to respectively T13 (surface site 1), a spinal column site 4 cm caudal to T13 (surface site 5), and a spinal column site 8 cm caudal to T13 (surface site 9). Off-contact surface irradiation of 3.14 W/cm2 at surface sites 1, 5, and 9 transmitted respectively 234.0 ± 120.7 μW/cm2, 230.7 ± 178.3 μW/cm2, and 130.2 ± 169.6 μW/cm2 to the spinal canal without the skin, and respectively 35.7 ± 33.2 μW/cm2, 50.9 ± 75.3 μW/cm2, and 15.7 ± 16.3 μW/cm2 with the skin. Transmission with skin was as low as 12% of the transmission without the skin. On-contact surface irradiation of 3.14 W/cm2 at surface sites 1, 5, and 9 transmitted respectively 44.6 ± 43.1 μW/cm2, 85.4 ± 139.1 μW/cm2, and 22.0 ± 23.6 μW/cm2 to the spinal canal. On-contact application increased transmission by a maximum of 67% comparing to off-contact application. The information gathered highlights the need to clinically consider the impact of skin transmission and on-contact application technique when attempting to treat spinal cord disease with PBM.
Literature
1.
Byrnes KR et al (2005) Light promotes regeneration and functional recovery and alters the immune response after spinal cord injury. Lasers Surg Med 36(3):171–185CrossRefPubMed
2.
de Andrade ALM, Bossini PS, Parizotto NA (2016) Use of low level laser therapy to control neuropathic pain: a systematic review. J Photochem Photobiol B Biol 164:36–42CrossRef
3.
Ramer LM, Ramer MS, Bradbury EJ (2014) Restoring function after spinal cord injury: towards clinical translation of experimental strategies. Lancet Neurol 13(12):1241–1256CrossRefPubMed
4.
Meireles A et al (2012) Avaliação do papel de opioides endógenos na analgesia do laser de baixa potência, 820 nm, em joelhos de ratos Wistar. Rev Dor 13(2):152–155CrossRef
5.
Serra AP, Ashmawi HA (2010) Influência da naloxona e metisergida sobre o efeito analgésico do laser em baixa intensidade em modelo experimental de dor. Rev Bras Anestesiol 60(3):302–310CrossRef
6.
7.
8.
Wu X et al (2009) 810 nm Wavelength light: an effective therapy for transected or contused rat spinal cord. Lasers Surg Med 41(1):36–41CrossRefPubMed
9.
Salehpour F et al (2017) Transcranial low-level laser therapy improves brain mitochondrial function and cognitive impairment in D-galactose-induced aging mice. Neurobiol Aging 58:140–150CrossRefPubMed
10.
Salehpour F et al (2018) Transcranial near-infrared photobiomodulation attenuates memory impairment and hippocampal oxidative stress in sleep-deprived mice. Brain Res 1682:36–43CrossRefPubMedPubMedCentral
11.
Karlekar A et al (2015) Assessment of feasibility and efficacy of class IV laser therapy for postoperative pain relief in off-pump coronary artery bypass surgery patients: a pilot study. Ann Card Anaesth 18(3):317CrossRefPubMedPubMedCentral
12.
Brock JA, McAllen RM (2016) Spinal cord thermosensitivity: an afferent phenomenon? Temperature 3(2):232–239CrossRef
13.
Janzadeh A et al (2017) Combine effect of chondroitinase ABC and low level laser (660 nm) on spinal cord injury model in adult male rats. Neuropeptides 65:90–99CrossRefPubMed
14.
Hu D, Zhu S, Potas JR (2016) Red LED photobiomodulation reduces pain hypersensitivity and improves sensorimotor function following mild T10 hemicontusion spinal cord injury. J Neuroinflammation 13(1):200CrossRefPubMedPubMedCentral
15.
Rochkind S et al (2002) Transplantation of embryonal spinal cord nerve cells cultured on biodegradable microcarriers followed by low power laser irradiation for the treatment of traumatic paraplegia in rats. Neurol Res 24(4):355–360CrossRefPubMed
16.
Paula AA et al (2014) Low-intensity laser therapy effect on the recovery of traumatic spinal cord injury. Lasers Med Sci 29(6):1849–1859CrossRefPubMed
17.
Veronez S et al (2017) Effects of different fluences of low-level laser therapy in an experimental model of spinal cord injury in rats. Lasers Med Sci 32(2):343–349CrossRefPubMed
18.
Sotoudeh A et al (2015) The influence of low-level laser irradiation on spinal cord injuries following ischemia-reperfusion in rats. Acta Cir Bras 30(9):611–616CrossRefPubMed
19.
da Silva T et al (2018) Effect of photobiomodulation treatment in the sublingual, radial artery region, and along the spinal column in individuals with multiple sclerosis: protocol for a randomized, controlled, double-blind, clinical trial. Medicine 97(19):e0627CrossRefPubMedPubMedCentral
20.
da Silva FC et al (2018) Photobiomodulation improves motor response in patients with spinal cord injury submitted to electromyographic evaluation: randomized clinical trial. Lasers Med Sci 33(4):883–890CrossRefPubMed
21.
Piao D et al (2018) Flexible nine-channel photodetector probe facilitated intraspinal multisite transcutaneous photobiomodulation therapy dosimetry in cadaver dogs. J Biomed Opt 23(1):010503CrossRef
22.
Saidu E et al (2013) 980 nm Wavelength light decreases mechanical allodynia in a rat neuropathic pain model. Lasers Surg Med 45:51–51
23.
Li X et al (2014) 980-nm infrared laser modulation of sodium channel kinetics in a neuron cell linearly mediated by photothermal effect. J Biomed Opt 19(10):105002CrossRefPubMed
24.
Anders JJ et al (2014) In vitro and in vivo optimization of infrared laser treatment for injured peripheral nerves. Lasers Surg Med 46(1):34–45CrossRefPubMed
25.
26.
Wu Q et al (2012) Low-level laser therapy for closed-head traumatic brain injury in mice: effect of different wavelengths. Lasers Surg Med 44(3):218–226CrossRefPubMedPubMedCentral
27.
28.
Pitzschke A et al (2015) Optical properties of rabbit brain in the red and near-infrared: changes observed under in vivo, postmortem, frozen, and formalin-fixated conditions. J Biomed Opt 20(2):25006CrossRefPubMed
29.
Sterzik V et al (2014) Spectrometric evaluation of post-mortem optical skin changes. Int J Legal Med 128(2):361–367CrossRefPubMed
30.
Wilson BC, Jeeves WP, Lowe DM (1985) In vivo and post mortem measurements of the attenuation spectra of light in mammalian tissues. Photochem Photobiol 42(2):153–162CrossRefPubMed
31.
Metadata
Title
Transcutaneous transmission of photobiomodulation light to the spinal canal of dog as measured from cadaver dogs using a multi-channel intra-spinal probe
Authors
Daqing Piao
Lara A. Sypniewski
Danielle Dugat
Christian Bailey
Daniel J. Burba
Luis DeTaboada
Publication date
01-10-2019
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 8/2019
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-019-02761-0

Other articles of this Issue 8/2019

Lasers in Medical Science 8/2019 Go to the issue

Review Article

Efficacy of laser treatment for onychomycotic nails: a systematic review and meta-analysis of prospective clinical trials

Original Article

Evaluation of nonlinear optical behavior of mouse colon cancer cell line CT26 in hyperthermia treatment

Letter to the Editor

Letter about outcome differences between recanalized malignant central airway obstruction from endoluminal disease versus extrinsic compression

Original Article

Changes in local skin temperature after the application of a pulsed Nd:YAG laser to healthy subjects: a prospective crossover controlled trial

Original Article

Low-level laser therapy affects dentinogenesis and angiogenesis of in vitro 3D cultures of dentin-pulp complex

Original Article

Dual-wavelength erbium-doped fluoride fiber laser