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01-09-2016 | Review

Transcriptional regulation of mast cell and basophil lineage commitment

Authors: Hua Huang, Yapeng Li, Bing Liu

Published in: Seminars in Immunopathology | Issue 5/2016

Abstract

Basophils and mast cells have long been known to play critical roles in allergic disease and in immunity against parasitic infection. Accumulated evidence also supports that basophils and mast cells have important roles in immune regulations, host defense against bacteria and viruses, and autoimmune diseases. However, origin and molecular regulation of basophil and mast cell differentiation remain incompletely understood. In this review, we focus on recent advances in the understanding of origin and molecular regulation of mouse and human basophil and mast cell development. A more complete understanding of how basophils and mast cells develop at the molecular level will lead to development of interventions that are more effective in achieving long-term success.

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Title: Transcriptional regulation of mast cell and basophil lineage commitment
Authors: Hua Huang
Yapeng Li
Bing Liu
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Seminars in Immunopathology / Issue 5/2016
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-016-0562-4

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Other articles of this Issue 5/2016

Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells

Basophil-derived IL-4 plays versatile roles in immunity

Regulatory roles of mast cells in immune responses

IgE and mast cells in host defense against parasites and venoms

Role of basophils in protective immunity to parasitic infections

New insights into basophil heterogeneity

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