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The participants underwent CMR imaging and right heart catheterization (RHC), carried out within 24 hours of each other, as well as invasive PCWP.

Aficamten improves oxygen uptake and other outcomes compared with placebo in patients with obstructive hypertrophic cardiomyopathy.

However, the investigators caution that the positive outcome is not generalizable to those with intracerebral hemorrhage in other locations and point out that “survival was associated with severe disability in both treatment groups.”

Further, the risk for developing congestive heart failure and other cardiovascular diseases, and the likelihood of requiring a cardiovascular procedure were also significantly higher in children with hypertension (HR=2.6, 1.7 and 2.6, respectively).

The other primary endpoint of OS in the full trial population did not reach statistical significance at the interim analysis, but it did so at the final analysis conducted at a median follow-up of 13.2 months.

The findings were also simultaneously presented at the ESC Heart Failure meeting held in Lisbon, Portugal. medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2024 Springer Healthcare Ltd, part of the Springer Nature Group J Am Coll Cardiol 2024; doi:10.1016/j.jacc.2024.03.426 J Am Coll Cardiol 2024; doi:10.1016/j.jacc.2024.04.013 Heart Failure 2024; Lisbon, Portugal: 11–14 May

They also note that “senaparib was associated with less frequent gastrointestinal toxicities than other PARP inhibitors, which indicates reduced potential for off-target effects.”

There were no significant differences detected among the treatment groups in the rates of other adverse events including hyponatremia, dyskalemia, metabolic acidosis, and symptomatic hypotension. medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2024 Springer Healthcare Ltd, part of the Springer Nature Group JACC: Heart Failure 2024; doi:10.1016/j.jchf.2024.04.014 ESC Heart Failure 2024; Lisbon, Portugal: May 11–14

The team notes that patients did not mention gastric rumbling and flushing, both of which have been commonly reported in other studies.

The pair suggests that if the delivery method of vitamin A is the main issue, then future research should focus on “other innovative routes,” in addition to concentrating on cohorts of infants who may be more likely to respond – such as those at lower risk for bronchopulmonary dysplasia, those with lower baseline vitamin A intake, and those in middle- and low-income countries.

The authors also comment that additional research is needed “to understand the long term effectiveness and cost effectiveness of increasing the use of SGLT-2 inhibitors for people with type 2 diabetes mellitus.” medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2024 Springer Healthcare Ltd, part of the Springer Nature Group BMJ 2024; 385 : e077097

Ryan and team suggest that this possibly reflects exposure to a higher level of drug in lower BMI categories but could also be related to other explanations, including differences in motivation.

“Confirmatory studies are warranted to determine whether our findings apply to birisk populations defined by other bleeding and risk criteria,” say Han et al, as well as to a Western population.