In industrialized countries, degenerative aortic stenosis (AS) and coronary artery disease (CAD) are considered to be the most prevalent cardiovascular diseases [ 1 ]. Pathophysiologically, atherosclerosis is the basis of both degenerative AS and …

Von Willebrand disease (VWD) is the most common inherited bleeding disorder in the world with a prevalence of up to 1% [ 1 ]. It is caused by missing or defective von Willebrand factor (VWF) [ 2 – 5 ]. However, the prevalence of affected …

Acquired von Willebrand syndrome (AVWS) is a rare hematologic disorder characterized by quantitative or qualitative defects of von Willebrand factor (vWF), a protein crucial for normal hemostasis. AVWS has been described in association with …

Type 3 von Willebrand disease (VWD), a rare and severe subtype, can produce inhibitors in roughly 5% to 10% of cases. We present a case of type 3 VWD with inhibitors in late pregnancy, which was successfully managed with a combination of …

von Willebrand disease (VWD) is a common bleeding disorder. It is seen mostly in female patients due to the occurrence in the high rate of obstetric and gynecologic problems such as heavy menstrual bleedings and postpartum hemorrhage [ 1 ]. The …

Older patients with bleeding disorders were frequently exposed to polypharmacy and complex medication regimens due to specific medications for bleeding disorders but also to medications for multiple comorbidities. Polypharmacy and MRCI score could …

Von Willebrand's disease (vWD) is the most common inherited bleeding disorder in humans with an incidence of 1–2% in the general population [ 1 ]. Von Willebrand’s disease is an autosomal hereditary bleeding disorder associated with a quantitative …

The proband’s von Willebrand factor (VWF) antigen and VWF collagen-binding capacity were 14% and 10%, respectively; his sister’s were 16% and 9%, respectively; and his nephew’s were 30% and 15%, respectively. No apparent loss of high-molecular …

Von Willebrand Disease (VWD) is characterized by a qualitative or quantitative defect in von Willebrand factor that results in prolonged bleeding due to the inability to form a stable platelet plug. VWD is the most common inherited bleeding …

Von Willebrand disease is the most common autosomal inherited bleeding disorder. It is caused by quantitative or qualitative defects of the von Willebrand factor. The International Society of Thrombosis and Hemostasis recognizes three types of Von …

Type 2 von Willebrand disease (VWD) is the most common congenital bleeding disorder, with variable bleeding tendency and a complex laboratory phenotype. In the current study, we report the clinical and molecular profile of a large number of …

Elevated von Willebrand factor (vWF):Antigen plasma levels have been observed in conjunction with cardiovascular diseases or vasculitis. The association of Kawasaki disease, a vascular inflammatory disease and vWF:Antigen, vWF:Collagen binding …

Background: Characterization of reticulo-endothelial activation in COVID-19 may guide treatment. Objectives: To assess reticulo-endothelial activation and its correlation with disease severity and death in patients across the entire spectrum of …

Type 2N von Willebrand disease (VWD) is characterized by impaired factor VIII (FVIII) binding to von Willebrand factor (VWF). Type 2N VWD patients generally exhibit mild bleeding tendency, but some exhibit a more severe hemorrhagic pattern. An …

Von Willebrand Factor (vWF) is a large glycoprotein with a broad range of physiological and pathological functions in health and disease. While vWF is critical for normal hemostasis, vascular integrity and repair, quantitative and qualitative …

Vonicog alfa (VONVENDI), a human recombinant form of von Willebrand factor (rVWF), is a valuable addition to the treatments available to treat bleeding episodes in adults with von Willebrand disease (VWD). It is a highly purified and homogenous …