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Tissue Plasminogen Activator 

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  1. Open Access 01-12-2024 | OriginalPaper

    Tissue-plasminogen activator effects on the phenotype of splenic myeloid cells in acute inflammation

    Tissue-plasminogen activator (tPA) is a serine protease well known for its fibrinolytic function. Recent studies indicate that tPA could also modulate inflammation via plasmin generation and/or by receptor mediated signalling in vitro. However …

  2. Open Access 02-11-2023 | Tissue Plasminogen Activator | ReviewPaper

    The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective

    Alzheimer’s disease (AD) is the most common type of dementia associated with amyloid beta (Aβ) deposition. Dysfunction of the neuronal clearance pathway promotes the accumulation of Aβ. The plasminogen-activating system (PAS) is controlled by …

  3. 15-09-2023 | Tissue Plasminogen Activator | OriginalPaper

    Impact of low-level laser therapy as an adjunct to non-surgical periodontal treatment on the levels of tissue plasminogen activator and plasminogen activator inhibitor 1 in Stage 3–4, Grade C periodontitis patients: a split-mouth, randomized control study

    Periodontitis is one of the most prevalent chronic diseases, affecting more than 65% of the population worldwide. The new 2018 Classification of Periodontal Diseases has provided a multidimensional characterization of periodontitis comprised of …

  4. Open Access 01-12-2022 | Diabetic Retinopathy | OriginalPaper

    Relationship between serum and tear levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in diabetic retinopathy

    Type 2 diabetes mellitus (T2DM) is an emerging global epidemic and a major concern for public health. It is associated with many debilitating macro- and micro-vascular complications. According to the International Diabetes Federation (IDF) 9 th …

  5. Open Access 01-12-2022 | Tissue Plasminogen Activator | OriginalPaper

    Tissue plasminogen activator with prolonged dwell time effectively evacuates pleural effusions

    Intrapleural fibrinolytic therapy can be an effective alternative to decortication for the management of complex pleural effusions. Tillet and Sherry were the first to explore this strategy [ 1 – 3 ], reporting in 1949 and 1951 on the …

  6. Open Access 01-12-2021 | Stroke | OriginalPaper

    Might life-threatening acute pulmonary edema occur after using recombinant tissue plasminogen activator? A case report

    Recombinant tissue plasminogen activator (rt-pa) is the first-line drug for the treatment of acute ischemic stroke [ 1 ], but rt-pa can lead to a variety of complications. The most common complications involve bleeding, such as intracranial …

  7. Open Access 01-12-2021 | Tissue Plasminogen Activator | OriginalPaper

    Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses

    Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by lymphoid and myeloid cell infiltration and microglial activation, leading to demyelination and progressive neurodegeneration [ 1 ]. Tissue plasminogen

  8. Open Access 01-12-2022 | Alteplase | OriginalPaper

    Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): study protocol for a phase 3, pan-European, two-group, non-commercial, active-control, observer-masked, superiority, randomised controlled surgical trial

    The numbers in curly brackets in this protocol refer to SPIRIT checklist item numbers. The order of the items has been modified to group similar items (see …

  9. 01-11-2021 | Stroke | OriginalPaper

    The use of recombinant tissue plasminogen activator in in acute ischemic stroke is associated with increased level of BDNF

    Much concern was directed towards the crucial role of recombinant tissue plasminogen activator (rt-PA) in improving neuroplasticity in patients with acute ischemic stroke. The aim of the work to investigate the effect of treating patients with …

  10. Open Access 01-12-2021 | Tissue Plasminogen Activator | OriginalPaper

    Substitution of citrate with tissue plasminogen activator (rt-PA) for catheter lock does not improve patency of tunnelled haemodialysis catheters in a randomised trial

    A number of guidelines and initiatives strongly recommend native arteriovenous fistulas (AVF) and discourage the use of catheters for chronic dialysis treatment [ 1 – 3 ]. This fistula first policy is based on evidence from large observational …

  11. Open Access 01-12-2021 | Stroke | OriginalPaper

    Phthalide derivative CD21 attenuates tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke by enhancing macrophage scavenger receptor 1-mediated DAMP (peroxiredoxin 1) clearance

    Stroke is the leading cause of morbidity and mortality in adults worldwide. Ischemic stroke accounts for > 80% of all stroke cases [ 1 ]. Cerebral hypoperfusion and oxygen/energy shortage are the main causes of brain injury in ischemic stroke.

  12. Open Access 01-12-2020 | Streptokinase | OriginalPaper

    Intrapericardial recombinant tissue plasminogen activator in purulent pericarditis- case series

    Purulent pericarditis (PP) is a rare cause of pericardial disease, with the prevalence of less than 3%, but with potentially life-threatening complication [ 1 ]. Most frequently PP develops in the course of bacterial infections of the head, neck or …

  13. 01-04-2021 | Tissue Plasminogen Activator | OriginalPaper

    Tissue Plasminogen Activator Loaded PCL Nanofibrous Scaffold Promoted Nerve Regeneration After Sciatic Nerve Transection in Male Rats

    According to the studies, damages to the peripheral nerve as a result of a trauma or acute compression, stretching, or burns accounts for a vast range of discomforts which strongly impressed the patient’s life quality. Applying highly potent …

  14. 01-05-2020 | Liver Transplantation | News

    Antineoplastics/heparin/unspecified recombinant tissue plasminogen activator

    Bilateral pulmonary thromboembolism and bleeding at surgical site due to contraindicated drug administration: case report
  15. Open Access 01-12-2023 | Tissue Plasminogen Activator | OriginalPaper

    Blood tissue Plasminogen Activator (tPA) of liver origin contributes to neurovascular coupling involving brain endothelial N-Methyl-D-Aspartate (NMDA) receptors

    Functional hyperemia, also named neurovascular coupling (NVC), allows adequate local energy supply to brain cells, with key roles in the pathophysiology of the brain [ 1 , 2 ]. For instance, brain disorders such as stroke or Alzheimer’s disease are …

  16. Open Access 01-12-2022 | OriginalPaper

    The choroid plexus: a door between the blood and the brain for tissue-type plasminogen activator

    The blood–brain barrier (BBB) has often been considered as being “the” barrier of the CNS. However, over the past 10 years, choroid plexuses (CP) have (re)emerged as another critical interface, fulfilling essential functions for CNS homeostasis [ …

  17. 26-07-2022 | Tissue Plasminogen Activator | Letter

    Tissue Plasminogen Activator (t-PA) in a Neonate with Hypernatremic Dehydration

  18. Open Access 01-12-2019 | Dabigatran | OriginalPaper

    Successful thrombolytic therapy with recombinant tissue plasminogen activator in ischemic stroke after idarucizumab administration for reversal of dabigatran: a case report

    Although direct oral anticoagulants (DOACs) are widely used for stroke prevention in patients with nonvalvular atrial fibrillation (NVAF), ischemic stroke can still occur in patients undergoing treatment with DOACs. Furthermore, when an ischemic …

  19. 01-09-2019 | Photodynamic Therapy | OriginalPaper

    Outcomes of vitrectomy combined with subretinal tissue plasminogen activator injection for submacular hemorrhage associated with polypoidal choroidal vasculopathy

    Submacular hemorrhage (SMH) is one of the major complications of polypoidal choroidal vasculopathy (PCV) and can cause sudden, severe, and permanent vision loss [ 1 , 2 ]. Whereas a thin SMH can be absorbed naturally, a thick SMH is rarely absorbed …

  20. Open Access 01-12-2022 | Alteplase | OriginalPaper

    Treatment of thrombosis in KD Patients using tissue plasminogen activator: a single center study

    Total 4 KD boys with thrombosis in CAA and convex to lumen were treated in Shengjing Hospital affiliated with China Medical University from January 2020 to August 2021. Data including ECG, ECHO, and CTA were collected for analysis in terms of CAA …

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