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Temperature Management 

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  1. Open Access 27-07-2023 | Temperature Management | BriefCommunication

    A Novel Technology for Targeted Brain Temperature Management

  2. Open Access 01-12-2023 | Temperature Management | OriginalPaper

    Novel serum biomarkers for predicting neurological outcomes in postcardiac arrest patients treated with targeted temperature management

    Accurate prognostication remains a crucial factor in the treatment of patients with unconscious postcardiac arrest syndrome (PCAS), primarily focusing on predicting the presence of severe brain damage and poor neurological outcome [ 1 – 4 ].

  3. 01-10-2022 | Temperature Management | OriginalPaper

    Through the Looking Glass: The Paradoxical Evolution of Targeted Temperature Management for Comatose Survivors of Cardiac Arrest

    For the past two decades, targeted temperature management (TTM) has been a staple in the care of comatose survivors following cardiac arrest. However, recent clinical trials have failed to replicate the benefit seen in earlier studies, bringing …

  4. Open Access 28-07-2022 | Analgesics in Dentistry | OriginalPaper

    Cardiac Arrest Treatment Center Differences in Sedation and Analgesia Dosing During Targeted Temperature Management

    Cardiac arrest survivors undergo targeted temperature management (TTM) after resuscitation to reduce brain injury and improve the likelihood of a good functional outcome. This period of critical care involves dozens of clinical decisions including …

  5. 01-04-2022 | Paracetamol

    Pre Versus Post Implementation of a Pharmacologic Antishivering Protocol During Targeted Temperature Management Following Cardiac Arrest

    Following cardiac arrest, cerebral ischemia occurs within 5 min of cessation of cerebral blood flow, leading to a cascade of deleterious reactions that result in neurologic injury. Secondary neurologic injury begins immediately after return of …

  6. Open Access 01-12-2022 | Myocardial Infarction | OriginalPaper

    Kinetics of 2 different high-sensitive troponins during targeted temperature management in out-of-hospital cardiac arrest patients with acute myocardial infarction: a post hoc sub-study of a randomised clinical trial

    Rise and fall of troponin levels following a period of ischemia provide important information about diagnosis of acute myocardial infarction (AMI) and infarct size [ 1 , 2 ]. Elevated troponins are also observed in patients with out-of-hospital …

  7. Open Access 01-12-2021 | Cardiopulmonary Resuscitation | OriginalPaper

    Reliability of prognostic biomarkers after prehospital extracorporeal cardiopulmonary resuscitation with target temperature management

    Out-of-hospital cardiac arrest (OHCA) is the prime cause of mortality in adults in developed industrial countries, with an overall survival rate of 10–30% [ 1 ]. The average global incidence of OHCA among adults is 95.9/100,000/year [ 1 – 3 ]. Even …

  8. 17-08-2022 | Temperature Management | EditorialNotes

    Manipulating temperature: devices for targeted temperature management (TTM) in brain injury

    Different devices have been developed to implement TTM in clinical practice that have progressively replaced less modern approaches, such as intravenous cold fluids, cold blankets, ice packs and pads. These systems, i.e. surface cooling devices …

  9. Open Access 17-12-2022 | Temperature Management | ReviewPaper

    Targeted Temperature Management in Cardiac Arrest: An Updated Narrative Review

    Survivors of cardiac arrest bear a substantial risk of neurological injury via hypoxic ischemic insult and reperfusion damage. Any survivor of cardiac arrest who is comatose should be considered as a candidate for targeted temperature management.

  10. Open Access 01-12-2022 | Temperature Management | OriginalPaper

    Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis

    Temperature control with target temperature management (TTM) after cardiac arrest has been endorsed by expert societies and adopted in international clinical practice guidelines [ 1 – 3 ] based on several randomised controlled trials (RCTs) …

  11. Open Access 01-07-2022 | Temperature Management | OriginalPaper

    Cost-Effectiveness Analysis of Intravascular Targeted Temperature Management after Cardiac Arrest in England

    Sudden cardiac arrest (SCA) is the third leading cause of death in Europe. Overall, less than 8% of patients experiencing out-of-hospital cardiac arrest (OHCA) survive to hospital discharge in England [ 1 ], an average that is also seen across …

  12. 01-09-2019 | Central Nervous System Trauma | EditorialNotes

    When less is more in the active management of elevated body temperature of ICU patients

    Fever is a broadly conserved biological response to infection across many animal species including insects, reptiles, fish, and mammals [ 4 ]. It is logical that a response that occurs in such diverse species has an evolutionary advantage …

  13. Open Access 01-12-2022 | Shock | OriginalPaper

    Outcomes of mild-to-moderate postresuscitation shock after non-shockable cardiac arrest and association with temperature management: a post hoc analysis of HYPERION trial data

    Postcardiac arrest syndrome is a complex combination of pathophysiological processes, including brain injury, myocardial dysfunction, and systemic ischemia/reperfusion injury with vasoplegia. A major component of this syndrome is hemodynamic …

  14. 01-04-2021 | Temperature Management | OriginalPaper

    Comparison of a Continuous Noninvasive Temperature to Monitor Core Temperature Measures During Targeted Temperature Management

    The detrimental effects of hyperthermia in the neurologically injured patient, along with the beneficial effects of normothermia, have been widely studied in the critically ill neurological population [ 1 – 3 ]. For these reasons, targeted …

  15. 01-10-2021 | Temperature Management | ReviewPaper

    Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets

    Out-of-hospital cardiac arrest (OHCA) is an important cause of morbidity and mortality worldwide. While there is geographic variation, incidence rates of OHCA are between 30 and 60 per 100,000 person-years, with only 11–30% of patients surviving …

  16. 08-07-2022 | Temperature Management | OriginalPaper

    Outcomes after decrease in hypothermia usage for out of Hospital Cardiac arrest after targeted temperature management study

    Out of hospital cardiac arrest (OHCA) with persistent comatose state is associated with high morbidity and mortality and is common with greater than 350,000 hospital presentations per year for OHCA in the United States.[ 1 ] Case reports, then …

  17. 16-06-2022 | Angiography | OriginalPaper

    Immediate coronary angiography and systematic targeted temperature management are associated with improved outcome in comatose survivors of cardiac arrest

    Rapid and systematic access to coronary angiography (CAG) and target temperature management (TTM) might improve outcome in comatose patients who survive cardiac arrest (CA). However, there is controversy around indicating immediate CAG in the …

  18. Open Access 01-12-2021 | Temperature Management | OriginalPaper

    Perioperative temperature management: a survey of 6 Asia–Pacific countries

    The past few decades have shown an increasing awareness of the physiological mechanisms and effects of temperature on perioperative morbidity and mortality [ 1 ]. Inadvertent perioperative hypothermia (IPH) has been defined as a core temperature

  19. Open Access 01-12-2022 | Shock | OriginalPaper

    Influence of temperature management at 33 °C versus normothermia on survival in patients with vasopressor support after out-of-hospital cardiac arrest: a post hoc analysis of the TTM-2 trial

    Induced hypothermia for neurologic protection after cardiac arrest has been established in experimental animal models [ 1 ]. Further, targeted temperature management (TTM) at a core body temperature of 33 °C (TTM33) has been a key component in …

  20. Open Access 01-12-2021 | Cardiopulmonary Resuscitation | Letter

    Targeted temperature management and cardiac arrest after the TTM-2 study

    The use of targeted temperature management (TTM) has been recommended for two decades in the management of patients after cardiac arrest; however, the quality of evidence behind this recommendation is moderate to low and refers only to …

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