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Parathyroid Disease 

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  1. 02-03-2024 | Pompe Disease | BriefCommunication

    Primary Multiglandular Parathyroid Disease in the Setting of Pompe Disease

    A woman in her 30 s presented with cardiomyopathy and hypercalcemia. She was found to have primary hyperparathyroidism. Imaging revealed 4 gland parathyroid disease. She underwent removal of 3-1/2 parathyroid glands.

  2. Open Access 01-06-2023 | Hyperparathyroidism | ReviewPaper

    Parathyroid diseases and metabolic syndrome

    Parathyroid diseases and metabolic syndrome are common clinical conditions that could share common pathways, interesting to investigate. Alterations in PTH homeostasis include: hyperparathyroidism (hyperPTH), hypoparathyroidism (hypoPTH) and …

  3. Open Access 01-12-2023 | Parathyroid Disease | ReviewPaper

    A contemporary analysis of the pre- and intraoperative recognition of multigland parathyroid disease

    Recently, the World Health Organisation (WHO) has proposed a new nomenclature for hyperparathyroidism [ 1 ]. For sporadic primary hyperparathyroidism in which more than one gland is autonomously secreting excess PTH the term multiglandular …

  4. 01-11-2020 | Hyperparathyroidism | OriginalPaper

    Type of subtotal parathyroidectomy and evolution of parathyroid hormone levels in end-stage renal disease patients: a retrospective cohort study

    More than 3 million people are suffering from chronic kidney disease (CKD) in Canada [ 1 ]. Mineral and bone disorders (MBD) are major complications of CKD which lead to bone anomalies and vascular calcification that are responsible for the high …

  5. Open Access 01-12-2021 | Arterial Diseases | OriginalPaper

    The impact of serum 25-hydroxyvitamin D, calcium, and parathyroid hormone levels on the risk of coronary artery disease in patients with diabetes: a Mendelian randomization study

  6. 01-10-2020 | Parathyroid Cancer | OriginalPaper

    Immunocyte density in parathyroid carcinoma is correlated with disease relapse

    Parathyroid carcinoma (PC) is a type of rare malignant endocrine neoplasm with a poor prognosis. The incidence of PC has reportedly increased in the US and Finland in recent years [ 1 , 2 ]. It accounts for less than 1% of primary …

  7. 01-01-2020 | Hyperparathyroidism | OriginalPaper

    Relationship between parathyroid oxyphil cell proportion and clinical characteristics of patients with chronic kidney disease

    The parathyroid glands of young and healthy subjects are mainly composed of chief cells. In the past, the chief cell was regarded as the only secretory cell in the parathyroid gland, which regulated the metabolism of calcium and phosphorus in the …

  8. 01-08-2019 | Chronic Kidney Disease | BriefCommunication

    Parathyroid suppression therapy normalizes chronic kidney disease-induced elevations in cortical bone vascular perfusion: a pilot study

    Chronic kidney disease–mineral and bone disorder (CKD-MBD), consisting of accelerated bone loss, vascular calcification, and abnormal biochemistries [ 1 ], contributes to an increased risk of premature death due to cardiovascular disease and …

  9. Open Access 01-12-2019 | Hyperparathyroidism | OriginalPaper

    Parathyroid carcinoma arising from auto-transplanted parathyroid tissue after Total Parathyroidectomy in chronic kidney disease patient: a case report

    Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease (CKD) [ 1 ]. Prompt treatment of secondary hyperparathyroidism is critical because it causes a mineral disturbance in the body and is associated with an …

  10. 01-09-2020 | Parathyroid Disease | ReviewPaper

    Hereditary Parathyroid Disease: Sometimes Pathologists Do Not Know What They Are Missing

    Parathyroid gland excision specimens are common and sometimes underestimated cases that many surgical pathologists encounter regularly. In the vast majority of cases, these will be spot diagnoses of sporadic primary parathyroid adenomas or …

  11. 01-01-2022 | Parathyroid Disease

    Clinicopathological variables that correlate with sestamibi positivity in uniglandular parathyroid disease: a retrospective analysis of 378 parathyroid adenomas

    Primary hyperparathyroidism (PHPT) is a common endocrine disease characterized by an autonomous, spontaneous overproduction of parathyroid hormone (PTH). With the exception of rare carcinomas, parathyroid adenomas are virtually the main cause of …

  12. 01-12-2020 | Hyperparathyroidism

    Severe chronic kidney disease environment reduced calcium-sensing receptor expression in parathyroid glands of adenine-induced rats even without high phosphorus diet

    Chronic kidney disease (CKD) is a global epidemic and public health problem, affecting human health in > 10% of the world population [ 1 ]. CKD is an independent predictor of all-cause mortality as well as cardiovascular mortality [ 2 ]; therefore …

  13. 01-08-2020 | Chronic Kidney Disease | OriginalPaper

    Changes in the whole/intact parathyroid hormone ratio and their clinical implications in patients with chronic kidney disease

    The kidney is responsible for maintaining serum calcium, serum phosphate, and bone metabolism balance via several pathways. From the early stages of chronic kidney disease (CKD), serum fibroblast growth factor 23 (FGF23) levels increase, active …

  14. Open Access 01-10-2020 | Parathyroid Disease | ReviewPaper

    Video-assisted neck surgery (VANS) using a gasless lifting procedure for thyroid and parathyroid diseases: “The VANS method from A to Z”

    Cosmetic outcome has always been an important consideration in thyroid and parathyroid surgery because the anterior neck is normally exposed, and thyroid diseases mainly affect women. Thus, thyroid surgeons have sought to improve the cosmetic …

  15. 10-05-2022 | Hypoparathyroidism | OriginalPaper

    Variation in parathyroid adenoma size in patients with sporadic, primary hyperparathyroidism: small gland size does not preclude single gland disease

    Parathyroidectomy is the only definitive cure for primary hyperparathyroidism (pHPT) and can provide durable cure in > 95% of patients [ 1 , 2 ]. Most patients with pHPT have a single parathyroid adenoma, with a variable rate (6–33%) of reported …

  16. 01-03-2020 | Hyperparathyroidism | OriginalPaper

    Hungry bone syndrome after parathyroidectomy in end-stage renal disease patients: review of an alkaline phosphatase-based treatment protocol

    CKD–MBD is a condition that involves a constellation of abnormalities seen in progressive kidney disease, including altered levels of calcium, phosphate, parathyroid hormone (PTH) and vitamin D. Secondary hyperparathyroidism (SHPT) is usually used …

  17. 01-11-2019 | Parathyroid Disease | OriginalPaper

    A Long, Unnerving Road: Malpractice Claims Involving the Surgical Management of Thyroid and Parathyroid Disease

    As the number of thyroid operations performed annually in the USA continues to increase [ 1 ], with an estimated 150,000 thyroidectomies and over 100,000 parathyroidectomies performed annually in the USA [ 2 , 3 ], postoperative complications and …

  18. 01-10-2019 | Hyperparathyroidism | OriginalPaper

    Parathyroid hormone independently predicts fracture, vascular events, and death in patients with stage 3 and 4 chronic kidney disease

    CKD affects one in five older adults [ 1 ] and 14% of the general population [ 2 ]. CKD causes more deaths per year than breast or prostate cancer [ 2 ]. Medicare spends nearly one-fifth of its budget on CKD patient care, due to excess vascular …

  19. Open Access 01-12-2020 | Hyperparathyroidism | OriginalPaper

    Impact of parathyroidectomy on left ventricular function in end stage renal disease patients

    The morbidity of secondary hyperparathyroidism is high in ESRD patients. Among all the complications, cardiovascular events are the leading causes of death, and the mortality caused by cardiovascular disease (CVD) is 10 to 100 times higher than …

  20. 01-03-2021 | OriginalPaper

    Intraoperative use of optical coherence tomography to differentiate normal and diseased thyroid and parathyroid tissues from lymph node and fat

    The purpose of this study is twofold: (1) to determine the feasibility of optical coherence tomography (OCT) to differentiate normal and diseased tissue of the neck region intraoperatively and (2) to evaluate how accurately a cohort of test …

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