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Neonatal Necrotizing Enterocolitis 

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  1. 02-04-2024 | Antibiotic | ReviewPaper

    Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention

    Necrotizing enterocolitis (NEC) is a life-threatening disease predominantly affecting premature and very low birth weight infants resulting in inflammation and necrosis of the small bowel and colon and potentially leading to sepsis, peritonitis …

  2. 01-12-2024 | Neonatal Necrotizing Enterocolitis | OriginalPaper

    MiRNA-192-5p-targeted activated leukocyte cell adhesion molecule improved inflammatory injury of neonatal necrotizing enterocolitis

    Neonatal necrotizing enterocolitis (NEC) is a critical illness in the neonatal period, with vomiting, diarrhea, and blood in the stool as the main clinical manifestations [ 1 , 2 ]. The prevalence of NEC in neonatal intensive care units is 1–5% …

  3. 01-12-2024 | OriginalPaper

    miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis

    Neonatal necrotizing enterocolitis (NEC) is one of the most common and serious gastrointestinal emergencies in neonates [ 1 ], characterized by diffuse or limited necrosis of the small intestine and colon, including the intestinal mucosa and even …

  4. 29-01-2024 | Neonatal Necrotizing Enterocolitis | OriginalPaper

    Surgical prediction of neonatal necrotizing enterocolitis based on radiomics and clinical information

    Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in neonates [ 1 ]. Approximately 2–5% of infants admitted to neonatal intensive care units (NICUs) have NEC, and 20–40% of them require surgical intervention.

  5. 01-12-2024 | OriginalPaper

    Evaluation of the protective and therapeutic effects of extra virgin olive oil rich in phenol in experimental model of neonatal necrotizing enterocolitis by clinical disease score, ınflammation, apoptosis, and oxidative stress markers

    Necrotizing enterocolitis (NEC) is an inflammatory disease of the gastrointestinal tract and is among the gastrointestinal system emergencies that is frequently observed especially in low-birth-weight premature infants and requires surgical …

  6. Open Access 30-06-2023 | Neonatal Necrotizing Enterocolitis | OriginalPaper

    NLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis

    Neonatal necrotizing enterocolitis (NEC) is one of the most common and severe bowel disease emergencies in neonates, especially preterm infants [ 1 , 2 ]. The overall morbidity and mortality of patients with NEC are high because most patients are …

  7. Open Access 01-12-2022 | Neonatal Necrotizing Enterocolitis | OriginalPaper

    Bioinformatics analysis of potential key genes and pathways in neonatal necrotizing enterocolitis

  8. 01-12-2023 | OriginalPaper

    Bovine milk-derived exosomes attenuate NLRP3 inflammasome and NF-κB signaling in the lung during neonatal necrotizing enterocolitis

    Necrotizing enterocolitis (NEC) is a common inflammatory intestinal disease of premature infants, with high morbidity and mortality rates. The disease can be described by intestinal necrosis of the ileum and/or colon and can present in different …

  9. 01-12-2023 | OriginalPaper

    Single-cell RNA sequencing of intestinal immune cells in neonatal necrotizing enterocolitis

    Necrotizing enterocolitis (NEC) causes inflammation and necrosis, and sometimes perforation, of the intestinal tract in neonates [ 1 ], resulting in life-threatening peritonitis that requires urgent surgery. With an incidence of 1 in 1000 births …

  10. Open Access 01-12-2021 | OriginalPaper

    Serum HMGB1 level is correlated with serum I-FABP level in neonatal patients with necrotizing enterocolitis

    Necrotizing enterocolitis (NEC) is the most serious intestinal disease in neonates, and has an estimated incidence of 6–7 % worldwide [ 1 ]. Furthermore, NEC has a very high mortality that ranges within 10–50 %, according to different researches [ …

  11. Open Access 01-12-2019 | OriginalPaper

    Experimental necrotizing enterocolitis induces neuroinflammation in the neonatal brain

    Necrotizing enterocolitis (NEC) is the most severe gastrointestinal neonatal emergency that primarily affects preterm infants with very low and extremely low birth weight [ 1 , 2 ]. NEC is characterized by an inflammation of the small and/or large …

  12. Open Access 01-12-2021 | Respiratory Microbiota | OriginalPaper

    Colonization of fecal microbiota from patients with neonatal necrotizing enterocolitis exacerbates intestinal injury in germfree mice subjected to necrotizing enterocolitis-induction protocol via alterations in butyrate and regulatory T cells

    Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that occurs in neonates. It is one of the most common disease-related causes of death among low birth weight babies, and the mortality rate associated with NEC may be as …

  13. Early versus late-onset necrotizing enterocolitis in very low birth infants in the neonatal intensive care unit

    Necrotizing enterocolitis (NEC), one of the most severe emergencies in neonates, is a multifactorial disease with risk factors such as early gestational age (GA), low birth weight, patent ductus arteriosus (PDA), artificial milk feeding, prolonged …

  14. 01-02-2022 | Septicemia | BriefCommunication

    COVID-19 pandemic in the neonatal intensive care unit: any effect on late-onset sepsis and necrotizing enterocolitis?

    The study was aimed at describing potential indirect effects of pandemic-related measures on very-low-birthweight infants in four Italian NICUs. No overall change in late-onset sepsis (LOS) and necrotizing enterocolitis was documented. However, in …

  15. Open Access 01-12-2020 | Intrauterine Growth Restriction | OriginalPaper

    Neonatal supraventricular tachycardia and necrotizing enterocolitis: case report and literature review

    Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency that mainly affects premature infants in neonatal intensive care units (NICUs). NEC is considered a multifactorial disease, and its pathogenesis is not yet completely …

  16. 01-06-2022 | Letter

    Neonatal Multisystem Inflammatory Syndrome (MIS-N) presenting as Necrotizing Enterocolitis and Cardiac Dysfunction

  17. Activated M1 macrophages suppress c-kit expression via TNF-α-mediated upregulation of miR-222 in Neonatal Necrotizing Enterocolitis

    Neonatal necrotizing enterocolitis (NEC) is the most common and fatal gastrointestinal emergency in newborns, particularly in premature infants, carrying a mortality rate of 20–50%[ 1 ]. It is thought to be a type of over-reactive intestinal …

  18. Open Access 01-12-2018 | ReviewPaper

    Current status of laboratory and imaging diagnosis of neonatal necrotizing enterocolitis

    Necrotizing enterocolitis continues to be a devastating disease process for very low birth weight infants in Neonatal Intensive Care Units. The aetiology and pathogenesis of necrotizing enterocolitis are not definitively understood. It is known …

  19. 01-11-2018 | OriginalPaper

    Clinical characteristic comparison of low birth weight and very low birth weight preterm infants with neonatal necrotizing enterocolitis: a single tertiary center experience from eastern China

    Neonatal necrotizing enterocolitis (NEC) is a clinical pathological syndrome, and is the most common neonatal acute abdomen characterized by progressive systemic and gastrointestinal symptoms [ 1 , 2 ]. However, the pathogenesis of NEC is …

  20. Open Access 01-12-2017 | OriginalPaper

    Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats

    Necrotizing enterocolitis (NEC) is a serious gastrointestinal disorder that frequently affects premature newborns and results in high morbidity and mortality, especially in very low-birth weight (VLBW) infants [ 1 , 2 ]. NEC affects approximately …

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