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4796 search results for:

Mitoxantrone 

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  1. 01-11-2023 | Mitoxantrone | OriginalPaper

    Multitargeted inhibitory effect of Mitoxantrone 2HCl on cervical cancer cell cycle regulatory proteins: a multitargeted docking-based MM\GBSA and MD simulation study

    Cervical cancer remains a significant global health concern that starts in the cervix, the lower part of the uterus that connects to the vagina and is caused by the human papillomavirus (HPV), necessitating the development of effective …

  2. 21-07-2023 | Mitoxantrone | OriginalPaper

    Treating relapsed B cell-precursor ALL in children with a setting-adapted mitoxantrone-based intensive chemotherapy protocol (TMH rALL-18 PROTOCOL) — experience from Tata Memorial Hospital, India

    The outlook of relapsed ALL in low- and middle-income countries (LMICs) is dismal due to high treatment-related toxicities and inadequate resources. We report our experience of using a locally adapted mitoxantrone-based protocol for non-high risk …

  3. Open Access 01-12-2023 | Acute Myeloid Leukemia | OriginalPaper

    Q-HAM: a multicenter upfront randomized phase II trial of quizartinib and high-dose Ara-C plus mitoxantrone in relapsed/refractory AML with FLT3-ITD

    Coordinating Investigator Prof. Dr. Richard F. Schlenk Trial Center Im Neuenheimer Feld 130/3 D-69120 Heidelberg Joint Coordinating Investigator Prof. Dr. Carsten Müller-Tidow Department of Internal Medicine V Heidelberg University Hospital Im …

  4. Open Access 01-03-2022 | Multiple Sclerosis | Report

    Marburg Multiple Sclerosis Variant: Complete Remission with Very Early Administration of Mitoxantrone—A Case Report

    Marburg variant is a severe and fulminant pseudotumor form of multiple sclerosis (MS) with high morbidity and mortality rates. Because of its scarcity, it remains incompletely characterized and physicians’ experiences will influence the treatment.

  5. Open Access 01-12-2021 | Prostate Cancer | OriginalPaper

    Bortezomib potentiates antitumor activity of mitoxantrone through dampening Wnt/β-catenin signal pathway in prostate cancer cells

    Wnt signaling is an evolutionarily highly conserved cellular pathway that is involved in embryogenesis, development, neoplasia, cell growth, organ formation, stem cell renewal, cell cycle progression, and survival [ 1 , 2 ]. Aberrant activation of …

  6. 01-01-2022 | Lymphoma

    A Retrospective Comparison of Mitoxantrone-Melphalan and BEAM Conditioning Regimens Before Autologous Hematopoietic Stem Cell Transplantation in Relapsed/Refractory Lymphoma Patients

    High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHSCT) is considered the standard therapy for patients with relapsed lymphoma. The aim of our study is the comparison of mitoxantrone-melphalan and BEAM …

  7. 21-04-2023 | Breast Cancer | OriginalPaper

    Safety and Efficacy of Mitoxantrone Hydrochloride Injection for Identification of Axillary Sentinel Lymph Nodes in Patients with Primary Breast Cancer

    In 2020, breast cancer ranked as the most common cancer, overtaking lung cancer, with 2.3 million newly diagnosed cases worldwide, accounting for 11.7% of all cancer cases diagnosed during this year [ 1 , 2 ].

  8. 01-08-2020 | Skin Graft | News

    Mitoxantrone

    Various toxicities following extravasation of mitoxantrone: case report
  9. 01-08-2020 | Chickenpox | News

    Mitoxantrone

    Various toxicities: 4 case reports
  10. 01-08-2022 | Ovarian Cancer | News

    Mitoxantrone

    Various toxicities: 10 case report
  11. 01-01-2019 | Acute Myeloid Leukemia | News

    Mitoxantrone

    Leukaemias, two malignancies and hypokinetic cardiomyopathy: 7 case reports
  12. Open Access 01-12-2022 | Neuroblastoma | OriginalPaper

    Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma

    Immune checkpoint inhibitors (ICI) have shown impressive clinical results against a variety of highly aggressive tumors, although durable benefits have only been observed in a limited fraction of patients [ 1 – 3 ]. The main reason for this …

  13. 01-07-2021 | Multiple Sclerosis | News

    Mitoxantrone/natalizumab

    Progressive multifocal leukoencephalopathy: case report
  14. 01-04-2019 | Acute Myeloid Leukemia | OriginalPaper

    Phase II study of FLAGM (fludarabine + high-dose cytarabine + granulocyte colony-stimulating factor + mitoxantrone) for relapsed or refractory acute myeloid leukemia

    Given the poor prognosis of patients with relapsed/refractory acute myeloid leukemia (AML), better therapy is needed. Fludarabine enhances the efficacy of Ara-C (cytarabine) by increasing intracellular Ara-C-triphosphate. The FLAG (fludarabine …

  15. 01-01-2021 | Multiple Sclerosis | News

    Mitoxantrone

    Liver failure: case report
  16. 01-04-2022 | Hyperpigmentation

    Efficacy and safety of mitoxantrone hydrochloride liposome injection in Chinese patients with advanced breast cancer: a randomized, open-label, active-controlled, single-center, phase II clinical trial

    Purpose. This trial aimed to evaluate the efficacy and safety of mitoxantrone hydrochloride liposome injection (Lipo-MIT) in advanced breast cancer (ABC). Methods. In this randomized, open-label, active-controlled, single-center, phase II clinical …

  17. 01-06-2020 | Cardiomyopathy | News

    Mitoxantrone/anthracyclines

    Cardiomyopathy: 15 case reports
  18. 01-12-2020 | Prostate Cancer | OriginalPaper

    Proteasome inhibitors attenuates mitoxantrone-triggered immunogenic cell death in prostate cancer cells

    Both mitoxantrone (MTX) and proteasome inhibitors efficiently trigger immunogenic cell death (ICD) in cancer cells. However, whether the combination of MTX and proteasome inhibitors can synergistically enhance ICD remains unknown. In this study …

  19. 01-12-2020 | Prostate Cancer | OriginalPaper

    Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression

    Cell death classification has evolved in the last one and a half centuries from solely morphology-based grouping to the inclusion of multiple parameters, such as morphological manifestations, biochemical features and functional outcomes [ 1 ].

  20. 01-01-2020 | Multiple Sclerosis | News

    Mitoxantrone

    Pancytopenia: case report

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