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986 search results for:

Megestrol Acetate 

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  1. 01-04-2024 | Megestrol Acetate | OriginalPaper

    Clinical implication of megestrol acetate in metastatic gastric cancer: a big data analysis from Health Insurance Review and Assessment (HIRA) database

    Cancer cachexia is a multifactorial syndrome characterized by an ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support [ 1 ]. Cancer cachexia is associated with a decline in performance status …

  2. Open Access 01-12-2022 | Fertility | OriginalPaper

    Levonorgestrel-releasing intrauterine device plus metformin, or megestrol acetate plus metformin for fertility-sparing treatment of atypical endometrial hyperplasia and early endometrial carcinoma: a prospective, randomized, blind-endpoint design trial protocol

    Endometrial adenocarcinoma (EC) is the fifth most common cancer in women worldwide [ 1 ]. Type 1 EC is typically associated with low-grade tumors with no or infiltrate the superficial muscularis, and with a good prognosis [ 2 ]. Endometrial …

  3. 01-12-2021 | Nifedipine

    Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor

    The treatment of cancer often needs a combination of multiple drugs supplemented with many symptomatic therapies, which increases the risk of adverse drug-drug interactions [ 1 ]. A significant element of these drug-drug interactions is the …

  4. 01-09-2019 | Malnutrition | OriginalPaper

    The effects of megestrol acetate on nutrition, inflammation and quality of life in elderly haemodialysis patients

    Due to the development of dialysis techniques and equipment, old age is no longer considered a contraindication for haemodialysis. In recent decades, a steadily increasing number of elderly patients worldwide have been diagnosed with end-stage …

  5. 01-02-2006 | OriginalPaper

    High prevalence of adrenal suppression during acute illness in hospitalized patients receiving megestrol acetate

    Introduction: Megestrol acetate (MA) is a progestational agent used for palliation of breast and endometrial cancer. The drug promotes weight gain via appetite stimulation. This property has led to widespread use in patients with wasting …

  6. 01-07-2018 | OriginalPaper

    Randomized double-blind clinical trial of combined treatment with megestrol acetate plus celecoxib versus megestrol acetate alone in cachexia-anorexia syndrome induced by GI cancers

    Cachexia affects physical, psychological, and social domains of life concomitantly [ 1 ]. As a result, quality of life of the cachexic patients declines dramatically. Current evidence suggests that cachexia develops following a prolonged systemic …

  7. 01-05-2005 | OriginalPaper

    The Science of Megestrol Acetate Delivery

    Potential to Improve Outcomes in Cachexia

    Cachexia, usually defined as the loss of >5% of an individual’s baseline bodyweight over 2–6 months, occurs with a number of diseases that includes not only AIDS and advanced cancer but also chronic heart failure, rheumatoid arthritis, chronic …

  8. 01-11-2007 | OriginalPaper

    Megestrol Acetate NCD Oral Suspension — Par Pharmaceutical

    Megestrol Acetate NanoCrystal® Dispersion Oral Suspension, PAR 100.2, PAR-100.21

    Par Pharmaceutical, Inc. has developed megestrol acetate (Megace® ES 625mg/5mL) oral suspension for the treatment of anorexia, cachexia or an unexplained, significant weight loss in patients with AIDS. Par Pharmaceutical used Elan Corporation’s …

  9. 01-07-2007 | OriginalPaper

    Megestrol Acetate NCD Oral Suspension — Par Pharmaceutical

    Megestrol Acetate NanoCrystal® Dispersion Oral Suspension, PAR 100.2, PAR-100.2

    Par Pharmaceutical has developed megestrol acetate (Megace® ES) oral suspension for the treatment of anorexia, cachexia and a significant weight loss associated with AIDS. Par Pharmaceutical used Elan Corporation’s NanoCrystal® Dispersion (NCD) …

  10. 01-05-2017 | OriginalPaper

    Comparing the Administration of Letrozole and Megestrol Acetate in the Treatment of Women with Simple Endometrial Hyperplasia without Atypia: A Randomized Clinical Trial

    Endometrial hyperplasia is identified with the excessive proliferation of the endometrial glands and may progress to or coexist with endometrial carcinoma [ 1 ]. An increased estrogen to progesterone ratio is the main mechanism involved in the …

  11. 01-04-2008 | OriginalPaper

    Megestrol acetate-induced adrenal insufficiency

    Megestrol acetate is a synthetic progestin that has been used since the 1970s for the treatment of advanced cancer and subsequently to treat anorexia, cachexia and weight loss in AIDS patients. It has been shown that high doses or prolonged …

  12. 01-01-1997 | OriginalPaper

    Augmentation of vincristine cytotoxicity by megestrol acetate

     Purpose: To determine the effect of a semisynthetic progesterone, megestrol acetate (MA), on the cytotoxicity of various chemotherapeutic agents including vincristine, doxorubicin, actinomycin-D, taxol, vinblastine and colchicine in cell lines …

  13. 01-12-2004 | OriginalPaper

    Tamoxifen and megestrol acetate for postmenopausal breast cancer

    Diverging effects on liver proteins, androgens, and glucocorticoids

    Aim: To compare the effects of tamoxifen and megestrol acetate on liver proteins, androgens, and glucocorticoids during adjuvant treatment for postmenopausal breast cancer.Methods: A subgroup of women within a large prospective multicenter trial …

  14. 01-10-2002 | Letter

    Does megestrol acetate down-regulate interleukin-6 in patients?

  15. 01-05-2011 | OriginalPaper

    Antiemetic activity of megestrol acetate in patients receiving chemotherapy

    Chemotherapy remains one of the standard treatments for cancer. The effective use of chemotherapy is limited by a wide range of side effects. Nausea and vomiting are among the most distressing and feared of these toxic effects [ 1 – 3 ] and the …

  16. 01-09-1999 | EditorialNotes

    Megestrol Acetate Treatment of Failure to Thrive in Congenital Heart Disease

  17. 01-10-2002 | Letter

    Does megestrol acetate down-regulate interleukin-6 in cancer-associated anorexia?

  18. 01-09-2002 | OriginalPaper

    Phase I and pharmacokinetic study of vinblastine and high-dose megestrol acetate

    AbstractPurpose. Preclinical data indicate that progestational agents (progesterone, medroxyprogesterone acetate and megestrol acetate) interact with p-glycoprotein (P-gp) and reverse P-gp-associated resistance to vinca alkaloids and other natural …

  19. 01-08-2010 | OriginalPaper

    Treatment of cancer-related anorexia with olanzapine and megestrol acetate: a randomized trial

    Cancer-related anorexia (CRA) is a loss of appetite associated with the systemic effects of cancer with a resulting loss of weight. Associated symptoms may include lack of appetite, early satiety, taste changes, poor performance status, and …

  20. Open Access 01-08-2012 | OriginalPaper

    Influence of megestrol acetate on nutrition, inflammation and quality of life in dialysis patients

    The number of end-stage renal disease (ESRD) patients is constantly increasing, including those requiring chronic renal replacement therapy. Despite the huge headway that has been made in dialysis techniques and equipment, the morbidity burden …

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