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Invasive Aspergillosis 

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  1. 16-04-2024 | Invasive Aspergillosis | Online First

    Evaluation of the JF5-based Aspergillus galactomannoprotein lateral flow device for diagnosing invasive aspergillosis in cancer patients

    Invasive aspergillosis (IA) is a life-threatening infectious disease that affects individuals with compromised immune function [ 1 ]. Cancer patients, including those with hematologic malignancies and solid tumours, are often in a state of …

  2. 12-02-2024 | Amphotericin B | OriginalPaper

    Risk factors for short-term prognosis of end-stage liver disease complicated by invasive pulmonary aspergillosis

    End-stage liver disease (ESLD) is often life-threatening due to severe complications such as comorbid infection, hemorrhage, ascites, hepatic encephalopathy, and hepatorenal syndrome. The 28-d mortality rate of acute-on-chronic liver failure …

  3. Open Access 01-12-2024 | Invasive Aspergillosis | OriginalPaper

    Age difference of patients with and without invasive aspergillosis: a systematic review and meta-analysis

    Aspergillus spp. are among the most common causes of fungal infections in humans and can cause a variety of diseases in immunocompromised individuals and those with chronic lung disorders [ 1 ]. Invasive aspergillosis (IA) is estimated to affect …

  4. Open Access 29-11-2023 | Invasive Aspergillosis | OriginalPaper

    Performance of the Aspergillus galactomannan lateral flow assay with a digital reader for the diagnosis of invasive aspergillosis: a multicenter study

    According to cutting-edge research by Fudan University in Shanghai, China, and the Global Action Fund for Fungal Infections (GAFFI), as many as 300,000 people worldwide are affected by invasive aspergillosis (IA), and currently, an estimated …

  5. Open Access 01-12-2023 | Adenovirus | OriginalPaper

    Severe pediatric adenoviral pneumonia combined with invasive pulmonary aspergillosis

    Adenoviral (ADV) pneumonia is one of the most serious types of community-acquired pneumonia in children [ 1 – 3 ]. It has received attention from physicians at all levels because of its severe clinical presentation, susceptibility to multisystem …

  6. 19-12-2023 | Aspergillosis | Online First

    Atypical Presentation of Invasive Aspergillosis in the Infralabial Region of the Face in an Immunocompetent Young Adult: A Case Report

    Aspergillosis is the second most common fungal infection. Aspergillosis can cause a wide range of clinical presentations from asymptomatic lesions to life-threatening invasive conditions. They originate most commonly from the spores that colonize …

  7. Open Access 01-12-2023 | Aspergillosis | OriginalPaper

    Bronchoalveolar lavage fluid polymerase chain reaction for invasive pulmonary aspergillosis among high-risk patients: a diagnostic meta-analysis

    Invasive pulmonary aspergillosis (IPA) is a common opportunistic fungal infection, contributing to high mortality in immunocompromised patients. Early diagnosis of IPA in patients at high risk is essential. It is estimated that more than 200,000 …

  8. Open Access 01-12-2023 | Voriconazole | OriginalPaper

    Efficacy and safety of voriconazole in the treatment of invasive pulmonary aspergillosis in patients with liver failure: study protocol for a randomized controlled clinical trial

    Title {1} Efficacy and safety of voriconazole in the treatment of invasive pulmonary aspergillosis in patients with liver failure: study protocol for a randomized controlled clinical trial Trial registration {2a and 2b} The trial was registered …

  9. Open Access 01-12-2023 | Myelodysplastic Syndrome | OriginalPaper

    Effect of invasive aspergillosis on risk for different causes of death in older patients with acute myeloid leukaemia or high-risk myelodysplastic syndrome

    The incidence of invasive aspergillosis (IA) in patients with haematological malignancies ranges from 4 (with prophylaxis) to 11% (without prophylaxis) during remission induction chemotherapy and is approximately 8% after allogeneic stem cell …

  10. Open Access 07-09-2023 | Voriconazole | OriginalPaper

    Pharmacokinetic and Exposure Response Analysis of the Double-Blind Randomized Study of Posaconazole and Voriconazole for Treatment of Invasive Aspergillosis

    Patients who are immunocompromised —including those with prolonged neutropenia, those who underwent allogeneic hematopoietic stem cell transplantation or solid organ transplantation, those with inherited or acquired immunodeficiencies, and those …

  11. 13-04-2023 | Aspergillosis | OriginalPaper

    Invasive cardiac aspergillosis in an immuno-competent patient: distinctive imaging features on 18F-fluorodeoxyglucose (FDG)-PET/CT and 99mTc-sestamibi SPECT myocardial perfusion imaging

    Aspergillus, the fungus responsible for aspergillosis, is ubiquitous in nature, and inhalation of infectious conidia is a frequent event. Most of the inhaled conidia are cleared by the host defenses, and therefore tissue invasion is uncommon …

  12. Open Access 01-12-2022 | Voriconazole | OriginalPaper

    Interaction between posaconazole and flucloxacillin in a lung transplant patient: decrease in plasma exposure of posaconazole and possible undertreatment of invasive aspergillosis: case report

    Voriconazole, posaconazole and isavuconazole are triazole antifungals used to treat invasive fungal infections, including pulmonary aspergillosis. Triazoles block ergosterol synthesis by inhibiting cytochrome P450 enzymes (CYP450), leading to …

  13. Open Access 01-12-2022 | Amphotericin B | OriginalPaper

    Successful treatment of invasive tracheobronchial pulmonary aspergillosis with venovenous extracorporeal membrane oxygenation and combined systemic, intratracheal instillation of liposomal amphotericin B: a case report

    Invasive pulmonary Aspergillus (IPA) is a life-threatening opportunistic fungal infection that predominantly affects immunocompromised hosts [ 1 ]. Invasive bronchial aspergillosis (ITBA) is rare, accounting for 7% of IPA cases [ 2 ]. ITBA is an …

  14. Open Access 01-12-2021 | Pentoxifylline | OriginalPaper

    Therapeutic effects of pentoxifylline on invasive pulmonary aspergillosis in immunosuppressed mice

    In recent years, the prevalence of invasive pulmonary aspergillosis (IPA) has increased significantly with an increasing population of immunosuppressed individuals at a high risk of infection [ 1 ]. Neutropenia is recognized as the primary risk …

  15. Open Access 18-03-2023 | Voriconazole | ReviewPaper

    Invasive Aspergillosis and the Impact of Azole-resistance

    The mold Aspergillus spp. was identified by an Italian priest Micheli in 1729, who named it after the shape of an Aspergillum (sprinkler of holy water) [ 1 ]. The classification of this mold is quite challenging. Since many informal classifications …

  16. Open Access 18-05-2023 | Aspergillosis | OriginalPaper

    A Comparison of Diagnostic Criteria for Invasive Pulmonary Aspergillosis in Critically Ill Patients

    Invasive pulmonary aspergillosis (IPA), a common opportunistic infection in the intensive care unit (ICU), is associated with increased mortality [ 1 – 4 ]. The reported incidence of IPA among critically ill patients varies widely from 9.4% to 69% …

  17. Open Access 01-12-2021 | Aspergillosis | OriginalPaper

    New clinical algorithm including fungal biomarkers to better diagnose probable invasive pulmonary aspergillosis in ICU

    The diagnosis of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) remains a challenge. Definitions of invasive fungal diseases were proposed in 2002, then updated in 2008 and in 2019, by a consensus group of the European …

  18. Open Access 01-12-2021 | Aspergillosis | OriginalPaper

    The role of pentraxin3 in plasma and bronchoalveolar lavage fluid in COPD patients with invasive pulmonary aspergillosis

    Invasive pulmonary aspergillosis (IPA) is a serious opportunistic infection caused by Aspergillus spp. In recent years, the incidence of IPA has gradually increased in patients with chronic obstructive pulmonary disease (COPD). Current research …

  19. 01-09-2021 | Aspergillosis

    Putative invasive pulmonary aspergillosis in apparently immunocompetent patients within medical wards and intensive care units

  20. 17-12-2022 | Aspergillosis | OriginalPaper

    COVID Associated Invasive Aspergillosis

    To study the possible association between invasive fungal sinusitis (aspergillosis) and coronavirus disease. An observational study was conducted at a tertiary care centre over 6 months, involving all patients with aspergillosis of the paranasal …

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