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Interstitial Lung Disease and Pulmonary Fibrosis 

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  1. Open Access 01-12-2023 | Pulmonary-Function Tests | OriginalPaper

    Clinical outcomes and risk factors of progressive pulmonary fibrosis in primary Sjögren’s syndrome-associated interstitial lung disease

    Interstitial lung disease (ILD) is a heterogeneous disorder characterized by inflammation and fibrosis of the lung parenchyma [ 1 , 2 ]. Idiopathic pulmonary fibrosis (IPF) is a prototype of progressive fibrosing ILD with poor prognosis. However …

  2. Open Access 12-12-2023 | Idiopathic Pulmonary Fibrosis | OriginalPaper

    Survival differences in rheumatoid arthritis interstitial lung disease and idiopathic pulmonary fibrosis may be explained by delays in presentation: results from multivariate analysis in a monocentric UK study

    Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) has a better prognosis compared to idiopathic pulmonary fibrosis (IPF). Recent data suggest that antifibrotics are effective in slowing progression across both groups. Hence, we …

  3. Open Access 13-10-2023 | Six Minute Walk Test | OriginalPaper

    Clinical effect of progressive pulmonary fibrosis on patients with connective tissue disease-associated interstitial lung disease: a single center retrospective cohort study

    The concept of progressive pulmonary fibrosis (PPF) has been introduced to predict the diverse prognosis of interstitial lung disease (ILD). However, the incidence and effect of PPF on outcomes in patients with connective tissue disease-associated …

  4. 03-05-2024 | Lung Ultrasound | Online First

    Screening value of lung ultrasound and pleural shear wave elastography in connective tissue disease–related interstitial lung disease: a preliminary study

    Connective tissue disease (CTD) comprises a group of immune system–mediated systemic autoimmune diseases characterized by tissue damage that can affect various organs [ 1 , 2 ]. Interstitial lung disease (ILD) is a common complication of CTD, and …

  5. 21-10-2023 | Idiopathic Pulmonary Fibrosis | OriginalPaper

    Plasma LTBP2 as a potential biomarker in differential diagnosis of connective tissue disease-associated interstitial lung disease and idiopathic pulmonary fibrosis: a pilot study

    Few biomarkers distinguish connective tissue disease-associated interstitial lung disease (CTD-ILD) from idiopathic pulmonary fibrosis (IPF). Latent transforming growth factor-β binding protein-2 (LTBP2), a secreted extracellular matrix protein …

  6. Open Access 01-12-2024 | Pneumothorax | OriginalPaper

    Native-lung complications following single-lung transplantation for interstitial lung disease: an in-depth analysis

    In performing lung transplantation (LTx) in regions with severe donor shortages, such as Japan, single-lung transplantation (SLTx) is often preferred over bilateral lung transplantation (BLTx) because of the critical need for available organs [ 1 – …3

  7. 20-11-2023 | Systemic Sclerosis | Erratum

    Correction to: Diagnosis of interstitial lung disease (ILD) secondary to systemic sclerosis (SSc) and rheumatoid arthritis (RA) and identification of ‘progressive pulmonary fibrosis’ using chest CT: a narrative review

  8. Open Access 01-12-2024 | Pneumothorax | OriginalPaper

    Assessment of a randomized controlled trial on the safety of pre-placing bronchial balloons in transbronchial lung cryobiopsy for diagnosing interstitial lung disease

    Interstitial lung diseases (ILD) are a heterogeneous group of disorders comprising more than 200 entities [ 1 ]. Although the clinical manifestations of ILD are similar in different entities, the corresponding therapeutic options differ, as well as …

  9. 06-10-2023 | Systemic Sclerosis | OriginalPaper

    Diagnosis of interstitial lung disease (ILD) secondary to systemic sclerosis (SSc) and rheumatoid arthritis (RA) and identification of ‘progressive pulmonary fibrosis’ using chest CT: a narrative review

    Interstitial lung disease (ILD) is a frequent manifestation of connective tissue diseases (CTDs), with incidence and prevalence variously assessed in the literature but reported in up to 30% of patients, with higher frequency in rheumatoid …

  10. 05-05-2024 | Rheumatoid Arthritis | Online First

    Multidimensional biomarker approach integrating tumor markers, inflammatory indicators, and disease activity indicators may improve prediction of rheumatoid arthritis-associated interstitial lung disease

    Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease predominantly characterized by joint inflammation, affecting a significant portion of the global population [ 1 ]. Notably, patients with RA frequently exhibit interstitial lung

  11. 09-03-2024 | Systemic Sclerosis | OriginalPaper

    Clinical characteristics of patients with connective tissue disease–related interstitial lung disease: a retrospective analysis

    Connective tissue diseases (CTDs) are a group of chronic inflammatory diseases that consist of Sjogren’s disease (SS), systemic sclerosis (SSc), rheumatoid arthritis (RA), mixt connective tissue disease (MCTD), idiopathic inflammatory myositis …

  12. Open Access 01-12-2024 | Lung Cancer | OriginalPaper

    Clinical characteristics and outcome of lung cancer in patients with fibrosing interstitial lung disease

    Interstitial lung diseases (ILDs) are a group of diffuse parenchymal lung disorders [ 1 ] that affect the pulmonary interstitial space [ 2 ]. An estimated number of more than 200 diseases have been reported to belong to ILD. Idiopathic pulmonary

  13. Open Access 01-12-2024 | Pneumonia | Letter

    Are there over 200 distinct types of interstitial lung diseases?

  14. Open Access 01-12-2024 | Systemic Sclerosis | ReviewPaper

    The role of lung biopsy for diagnosis and prognosis of interstitial lung disease in systemic sclerosis: a systematic literature review

    Systemic sclerosis (SSc) is a connective tissue disease characterized by microvascular alterations, excessive collagen deposition and autoimmune dysregulation, mainly affecting women (female:male ranging from 3–8:1) with a peak of disease is …

  15. Open Access 06-04-2024 | Computed Tomography | Online First

    Volume changes of diseased and normal areas in progressive fibrosing interstitial lung disease on inspiratory and expiratory computed tomography

    Progressive fibrosing interstitial lung disease (PF-ILD) is often difficult to treat. In many patients with PF-ILD, the disease progresses irreversibly, eventually leading to respiratory failure of varying severities. Many findings have been …

  16. Open Access 01-12-2024 | Idiopathic Pulmonary Fibrosis | OriginalPaper

    Disease trajectories in interstitial lung diseases – data from the EXCITING-ILD registry

    Interstitial lung diseases (ILD) comprise more than 200 mainly chronic diseases affecting the lung parenchyma due to inflammation and/or fibrosis [ 1 , 2 ]. The multidisciplinary diagnostic process considers clinical, radiological, and pathological …

  17. 01-03-2024 | Acenocoumarol | News

    Genetic variants contribute to drug-induced interstitial lung diseases

  18. Open Access 01-12-2024 | Dermatomyositis | OriginalPaper

    Elevated serum B-cell activator factor levels predict rapid progressive interstitial lung disease in anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis

    Anti-melanoma differentiation-associated gene 5 antibody positive (anti-MDA5 + ) dermatomyositis (DM) is a specific subtype of DM and is also known as clinically amyopathic dermatomyositis (CADM). Anti-MDA5 + DM is characterized with subtle or no …

  19. 20-04-2024 | Pulmonary-Function Tests | Online First

    Association between anti-PL7 antibodies and increased fibrotic component in patients with antisynthetase syndrome and interstitial lung disease: a cross-sectional study

    Antisynthetase syndrome (ASSD) is a systemic autoimmune disease characterized by autoantibody positivity against aminoacyl-tRNA synthetase (anti-ARS), including anti-Jo1 (anti-histidyl), anti-PL7 (anti-threonyl), anti-PL12 (anti-alanyl), anti-EJ …

  20. Open Access 01-12-2024 | Spirometry | OriginalPaper

    Feasibility and acceptability of remotely monitoring spirometry and pulse oximetry as part of interstitial lung disease clinical care: a single arm observational study

    Interstitial lung disease (ILD) is used to describe a group of diseases with differing aetiology that share clinical, radiological and histopathological features of progressive fibrosis or inflammation of the lung parenchyma. Both inflammation and …

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