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40495 search results for:

IL-6 Receptor Inhibitor 

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  1. Open Access 15-04-2023 | Methotrexate | OriginalPaper

    Comparative effectiveness of TNF inhibitor vs IL-6 receptor inhibitor as monotherapy or combination therapy with methotrexate in biologic-experienced patients with rheumatoid arthritis: An analysis from the CorEvitas RA Registry

    Rheumatoid arthritis (RA) is a global public health challenge, with increasing rates of age-standardized point prevalence and annual incidence [ 1 ]. If inadequately treated, RA may cause joint damage, disability, and other sequelae that impact the …

  2. Open Access 01-12-2024 | Rheumatoid Arthritis | OriginalPaper

    Management and treatment outcomes of rheumatoid arthritis in the era of biologic and targeted synthetic therapies: evaluation of 10-year data from the KURAMA cohort

    Treatment options for rheumatoid arthritis (RA) have progressed over the past two decades. Methotrexate (MTX), biologic disease-modifying antirheumatic drugs (bDMARDs), and targeted synthetic antirheumatic drugs (tsDMARDs) such as Janus kinase …

  3. Open Access 16-02-2023 | Disease Modifying Anti-Rheumatic Drug | ReviewPaper

    The efficacy and safety of olokizumab for rheumatoid arthritis: a systematic review, pairwise, and network meta-analysis

    Olokizumab (OKZ) is a novel IL-6 inhibitor that directly targets IL-6 rather than its receptor. We aim to evaluate the efficacy and safety of OKZ for patients with rheumatoid arthritis (RA) and to investigate the optimal treatment regimen. A …

  4. 18-05-2024 | Neuropathic Pain | Online First

    HDAC inhibitors as a potential therapy for chemotherapy-induced neuropathic pain

    Cancer, a chronic disease characterized by uncontrolled cell development, kills millions of people globally. The WHO reported over 10 million cancer deaths in 2020. Anticancer medications destroy healthy and malignant cells. Cancer treatment …

  5. Open Access 01-12-2024 | ReviewPaper

    Regulatory mechanisms of PD-1/PD-L1 in cancers

    Immune evasion contributes to cancer growth and progression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions. The programmed death protein 1 (PD-1) and programmed cell death …

  6. Open Access 01-12-2024 | Glioblastoma | ReviewPaper

    Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives

    Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a formidable challenge due to its immunosuppressive microenvironment, thereby confounding conventional therapeutic interventions. Despite the established treatment …

  7. 01-08-2024 | ReviewPaper

    The use of biologics and JAK inhibitors in the management of moderate to severe Hidradenitis Suppurativa treatment: a scoping review

    This scoping review aims to characterize the use of biologics and Janus Kinase inhibitors (JAKi) in the treatment of Hidradenitis Suppurativa (HS), which is a chronic inflammatory condition. A comprehensive literature search was conducted in …

  8. 20-05-2024 | Alzheimer's Disease | Online First

    The regulating effect of curcumin on NF-κB pathway in neurodegenerative diseases: a review of the underlying mechanisms

    Neurodegenerative diseases are part of the central nervous system (CNS) disorders that indicate their presence with neuronal loss, neuroinflammation, and increased oxidative stress. Several pathophysiological factors and biomarkers are involved in …

  9. Open Access 19-05-2024 | Rheumatoid Arthritis | Online First

    Biologics Versus JAK Inhibitors. Part I: Cancer Risk. A Narrative Review

    Conventional immunosuppressants such as corticosteroids, cyclosporine, methotrexate, or azathioprine present a significant burden of side effects (AEs) [ 1 ], including cytopenias (methotrexate or azathioprine), renal dysfunction or hypertension …

  10. Open Access 16-03-2024 | Spondyloarthropathy | ReviewPaper

    JAK-STAT Signaling and Beyond in the Pathogenesis of Spondyloarthritis and Their Clinical Significance

    Janus kinase–signal transducers and activators of transcription cell signaling proteins (JAK-STATs) play a crucial role in pathogenesis of several autoimmune conditions. The Janus kinases, also known as JAKs, are a group of intracellular molecules …

  11. Open Access 01-12-2024 | Breast Cancer | ReviewPaper

    Modulation of the tumor microenvironment and mechanism of immunotherapy-based drug resistance in breast cancer

    Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer is more challenging and may be unresponsive to conventional therapy. Immunotherapy is crucial for …

  12. Open Access 14-05-2024 | Stroke | Online First

    HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation

    Stroke in China is distinguished by its high rates of morbidity, recurrence, disability, and mortality. The ultra-early administration of rtPA is essential for restoring perfusion in acute ischemic stroke, though it concurrently elevates the risk …

  13. Open Access 01-05-2024 | Colorectal Cancer | ReviewPaper

    Role played by MDSC in colitis-associated colorectal cancer and potential therapeutic strategies

    Colitis-associated colorectal cancer has been a hot topic in public health issues worldwide. Numerous studies have demonstrated the significance of myeloid-derived suppressor cells (MDSCs) in the progression of this ailment, but the specific …

  14. Open Access 09-05-2024 | Cytokines | ReviewPaper

    Tumor Necrosis Factor and Interleukin Modulators for Pathologic Pain States: A Narrative Review

    Chronic pain, a complex and debilitating condition, involves intricate interactions between central and peripheral inflammatory processes. Cytokines, specifically tumor necrosis factor (TNF) and interleukins (IL), are key mediators in the …

  15. Open Access 01-12-2024 | Peritoneal Cancer | ReviewPaper

    Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis

    Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a poor prognosis and limited treatment options. Recent work identifying high concentrations of the cytokine interleukin-6 (IL-6) and its soluble receptor

  16. 25-05-2024 | Online First

    Beyond Immune Checkpoint Inhibitors: Emerging Targets in Melanoma Therapy

    The advent of modern therapeutics targeting BRAF and immune-checkpoint blockade has driven clinical improvement for patients with melanoma. Prior to the introduction of immune checkpoint inhibitors (ICIs) and targeted therapy, metastatic melanoma …

  17. Open Access 01-12-2024 | Post-COVID Syndrome | ReviewPaper

    Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration

    The unprecedented pandemic of COVID-19 swept millions of lives in a short period, yet its menace continues among its survivors in the form of post-COVID syndrome. An exponentially growing number of COVID-19 survivors suffer from cognitive …

  18. Open Access 01-12-2024 | Colorectal Cancer | ReviewPaper

    The multifaceted role of extracellular vesicles (EVs) in colorectal cancer: metastasis, immune suppression, therapy resistance, and autophagy crosstalk

    Extracellular vesicles (EVs) are lipid bilayer structures released by all cells and widely distributed in all biological fluids. EVs are implicated in diverse physiopathological processes by orchestrating cell–cell communication. Colorectal cancer …

  19. 23-05-2024 | Pruritus | Online First

    Title: Pruritus in the Elderly: Differential Diagnosis and Management

    Pruritus, commonly known as “itching”, is an exclusively cutaneous sensation that produces a desire to scratch the affected region. The sensation is produced by a complex pathway involving keratinocytes as the initial responder, which subsequently …

  20. Open Access 18-05-2024 | Metastasis | Online First

    Targeting CD44 and other pleiotropic co-receptors as a means for broad inhibition of tumor growth and metastasis

    Although progress has been made in the treatment of cancer, particularly for the four major types of cancers affecting the lungs, colon, breast and prostate, resistance to cancer treatment often emerges upon inhibition of major signaling pathways …

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